Abrogation of DEN/Fe-NTA induced carcinogenic response, oxidative damage and subsequent cell proliferation response by Terminalia chebula in kidney of Wistar rats
Language: 
English
Abstract: 

In an effort to identify a new chemopreventive agent, the present study was conducted to investigate the role of T. chebula in the prevention of ferric nitrilotriacetic acid (Fe- NTA) induced oxidative stress and renal tumorigenesis in Wistar rats. A single application of Fe-NTA (9 mg Fe/kg body weight, intraperitoneally) significantly induced oxidative stress and elevated the marker parameters of tumor promotion. However, the pretreatment of animals with different doses of T. chebula extract (25 and 50 mg/kg body weight) restored the levels of reduced glutathione (GSH) and cellular protective enzymes (p < 0.05). Concomitantly, malondialdehyde (MDA) formation and hydrogen peroxide content were also reduced significantly (p < 0.05) at both the doses. The promotion parameters tested (ornithine decarboxylase activity and DNA synthesis) were also significantly suppressed (p < 0.05). T. chebula also inhibited N-diethyl nitrosamine initiated renal carcinogenesis by showing reduction in the number of animals with renal cell tumors and percentage incidence of tumor as compared to the DEN initiated and Fe-NTA promoted rats. The study was further histologically confirmed. These results suggest a potential role of T. chebula in protection from Fe-NTA-induced renal carcinogenesis and oxidative damage.

Author(s): 
Prasad, L.
Khan, T. H.
Jahangir, T.
Sultana, S.
Item Type: 
Journal Article
Publication Title: 
Die Pharmazie
Journal Abbreviation: 
Pharmazie
Publication Date: 
2007-10
Publication Year: 
2007
Pages: 
790-797
Volume: 
62
Issue: 
10
ISSN: 
0031-7144
Library Catalog: 
PubMed
Extra: 
PMID: 18236787

Turabian/Chicago Citation

L. Prasad, T. H. Khan, T. Jahangir and S. Sultana. 2007-10. "Abrogation of DEN/Fe-NTA induced carcinogenic response, oxidative damage and subsequent cell proliferation response by Terminalia chebula in kidney of Wistar rats." Die Pharmazie 62: 10: 790-797.

Wikipedia Citation

<ref> {{Cite journal | doi = | issn = 0031-7144 | volume = 62 | pages = 790-797 | last = Prasad | first = L. | coauthors = Khan, T. H., Jahangir, T., Sultana, S. | title = Abrogation of DEN/Fe-NTA induced carcinogenic response, oxidative damage and subsequent cell proliferation response by Terminalia chebula in kidney of Wistar rats | journal = Die Pharmazie | date = 2007-10 | pmid = | pmc = }} </ref>