Acupuncture for neurogenesis in experimental ischemic stroke: a systematic review and meta-analysis
Language: 
English
Short Title: 
Acupuncture for neurogenesis in experimental ischemic stroke
Abstract: 

Acupuncture has been used for patients with stroke and post-stroke rehabilitation for thousands of years. Previous studies reported that acupuncture enhanced stroke recovery through neurogenesis. Hence, we conducted a systematic review and meta-analysis for preclinical studies to assess the current evidence for acupuncture effect on neurogenesis in treating ischaemic stroke. Studies were obtained from six databases, including PubMed, EMBASE, Cochrane Library, Chinese National Knowledge Infrastructure, VIP information database, and Chinese Biomedical Literature Database, Ultimately, 34 studies containing 1617 animals were identified. Neurogenesis markers of Brdu, Nestin, PSA-NCAM, NeuN and GFAP were selected as major outcomes. The pooled results of 15 studies marked with Brdu showed significant effects of acupuncture for improving proliferation when compared with control groups (P?<?0.01); 13 studies marked with Nestin showed significant effects of acupuncture for increasing proliferation when compared with control groups (P?<?0.01); 4 studies marked with PSA-NCAM showed significant effects of acupuncture for enhancing migration when compared with control groups (P?<?0.01); 4 studies marked with NeuN showed significant effects of acupuncture for stimulating differentiation when compared with control groups (P?<?0.01). The findings suggest that acupuncture is a prospective therapy targeting neurogenesis for ischemic stroke.

Author(s): 
Lu, Lin
Zhang, Xiao-guang
Zhong, Linda L. D.
Chen, Zi-xian
Li, Yan
Zheng, Guo-Qing
Bian, Zhao-Xiang
Item Type: 
Journal Article
Publication Title: 
Scientific Reports
Journal Abbreviation: 
Sci Rep
Publication Date: 
1/20/2016
Publication Year: 
2016
Pages: 
19521
Volume: 
6
ISSN: 
2045-2322
DOI: 
10.1038/srep19521
Library Catalog: 
PubMed
Extra: 
PMID: 26786869 PMCID: PMC4726177

Turabian/Chicago Citation

Lin Lu, Xiao-guang Zhang, Linda L. D. Zhong, Zi-xian Chen, Yan Li, Guo-Qing Zheng and Zhao-Xiang Bian. 1/20/2016. "Acupuncture for neurogenesis in experimental ischemic stroke: a systematic review and meta-analysis." Scientific Reports 6: 19521. 10.1038/srep19521.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1038/srep19521 | issn = 2045-2322 | volume = 6 | pages = 19521 | last = Lu | first = Lin | coauthors = Zhang, Xiao-guang, Zhong, Linda L. D., Chen, Zi-xian, Li, Yan, Zheng, Guo-Qing, Bian, Zhao-Xiang | title = Acupuncture for neurogenesis in experimental ischemic stroke: a systematic review and meta-analysis | journal = Scientific Reports | date = 1/20/2016 | pmid = | pmc = }} </ref>