Annual Research Review: Epigenetic mechanisms and environmental shaping of the brain during sensitive periods of development
Language: 
English
Short Title: 
Annual Research Review
Abstract: 

Experiences during early development profoundly affect development of the central nervous system (CNS) to impart either risk for or resilience to later psychopathology. Work in the developmental neuroscience field is providing compelling data that epigenetic marking of the genome may underlie aspects of this process. Experiments in rodents continue to show that experiences during sensitive periods of development influence DNA methylation patterns of several genes. These experience-induced DNA methylation patterns represent stable epigenetic modifications that alter gene transcription throughout the lifespan and promote specific behavioral outcomes. We discuss the relevance of these findings to humans, and also briefly discuss these findings in the broader contexts of cognition and psychiatric disorder. We conclude by discussing the implications of these observations for future research.

Author(s): 
Roth, Tania L.
Sweatt, J. David
Item Type: 
Journal Article
Publication Title: 
Journal of Child Psychology and Psychiatry, and Allied Disciplines
Journal Abbreviation: 
J Child Psychol Psychiatry
Publication Date: 
2011-04
Publication Year: 
2011
Pages: 
398-408
Volume: 
52
Issue: 
4
ISSN: 
1469-7610
DOI: 
10.1111/j.1469-7610.2010.02282.x
Library Catalog: 
PubMed
Extra: 
PMID: 20626526 PMCID: PMC2965301

Turabian/Chicago Citation

Tania L. Roth and J. David Sweatt. 2011-04. "Annual Research Review: Epigenetic mechanisms and environmental shaping of the brain during sensitive periods of development." Journal of Child Psychology and Psychiatry, and Allied Disciplines 52: 4: 398-408. 10.1111/j.1469-7610.2010.02282.x.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1111/j.1469-7610.2010.02282.x | issn = 1469-7610 | volume = 52 | pages = 398-408 | last = Roth | first = Tania L. | coauthors = Sweatt, J. David | title = Annual Research Review: Epigenetic mechanisms and environmental shaping of the brain during sensitive periods of development | journal = Journal of Child Psychology and Psychiatry, and Allied Disciplines | date = 2011-04 | pmid = | pmc = }} </ref>