Antioxidant activity of ethanolic extract of Terminalia chebula fruit against isoproterenol-induced oxidative stress in rats
Language: 
English
Abstract: 

Antioxidant activity of ethanolic extract of fruits of Terminalia chebula (500 mg/kg body wt, orally for 30 days) against isoproterenol-induced oxidative stress was investigated in rats. The levels of serum lipid peroxides, iron, ascorbic acid, vitamin E, plasma iron-binding capacity, and the activities of ceruloplasmin and glutathione were assayed, in addition to the activities of the antioxidant enzymes--glutathione peroxidase, glutathione reductase, glutathione-S-transferase, superoxide dismutase and catalase in the heart tissue. Administration of isoproterenol increased the levels of lipid peroxides and iron, with corresponding decrease in the activities of the enzymic and non-enzymic antioxidants. The pre-treatment with ethanolic extract of fruits significantly prevented the alterations induced by isoproterenol, and maintained a near normal antioxidant status. Results suggest that the cardioprotective effect of T. chebula fruit may partly be attributed to its antioxidant properties.

Author(s): 
Suchalatha, Subramaniyan
Srinivasulu, Chennam
Devi, Shyamala
Item Type: 
Journal Article
Publication Title: 
Indian Journal of Biochemistry & Biophysics
Journal Abbreviation: 
Indian J. Biochem. Biophys.
Publication Date: 
2005-08
Publication Year: 
2005
Pages: 
246-249
Volume: 
42
Issue: 
4
ISSN: 
0301-1208
Library Catalog: 
PubMed
Extra: 
PMID: 23923550

Turabian/Chicago Citation

Subramaniyan Suchalatha, Chennam Srinivasulu and Shyamala Devi. 2005-08. "Antioxidant activity of ethanolic extract of Terminalia chebula fruit against isoproterenol-induced oxidative stress in rats." Indian Journal of Biochemistry & Biophysics 42: 4: 246-249.

Wikipedia Citation

<ref> {{Cite journal | doi = | issn = 0301-1208 | volume = 42 | pages = 246-249 | last = Suchalatha | first = Subramaniyan | coauthors = Srinivasulu, Chennam, Devi, Shyamala | title = Antioxidant activity of ethanolic extract of Terminalia chebula fruit against isoproterenol-induced oxidative stress in rats | journal = Indian Journal of Biochemistry & Biophysics | date = 2005-08 | pmid = | pmc = }} </ref>