Caloric restriction: is mammalian life extension linked to p53?
Language: 
English
Short Title: 
Caloric restriction
Abstract: 

Caloric restriction, that is limiting food intake, is recognized in mammals as the best characterized and most reproducible strategy for extending lifespan, retarding physiological aging and delaying the onset of age-associated diseases. The aim of this mini review is to argue that p53 is the connection in the abilities of both the Sirt-1 pathway and the TOR pathway to impact on longevity of cells and organisms. This novel, lifespan regulating function of p53 may be evolutionarily more ancient than its relatively recent role in apoptosis and tumour suppression, and is likely to provide many new insights into lifespan modulation.

Author(s): 
Tucci, Paola
Item Type: 
Journal Article
Publication Title: 
Aging
Journal Abbreviation: 
Aging (Albany NY)
Publication Date: 
2012-08
Publication Year: 
2012
Pages: 
525-534
Volume: 
4
Issue: 
8
ISSN: 
1945-4589
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 22983298 PMCID: PMC3461340

Turabian/Chicago Citation

Paola Tucci. 2012-08. "Caloric restriction: is mammalian life extension linked to p53?." Aging 4: 8: 525-534.

Wikipedia Citation

<ref> {{Cite journal | doi = | issn = 1945-4589 | volume = 4 | pages = 525-534 | last = Tucci | first = Paola | coauthors = | title = Caloric restriction: is mammalian life extension linked to p53? | journal = Aging | date = 2012-08 | pmid = | pmc = }} </ref>