Cardio-hepatic metabolic derangements and valproic acid
Language: 
English
Abstract: 

Valproic acid (VPA) is an anti-epileptic and mood-stabilizing compound successfully used in the clinics since many decades. During the last few years, research on VPA revitalized. VPA has profound impact on nuclear chromatin structure in target cells by impinging on epigenetic mechanisms such as inhibition of histone deacetylase HDAC1, with implications for HIV and cancer treatment, and for the direct reprogramming in generation of induced pluripotent stem (iPS) cells. VPA can thus act at multiple levels and in several cellular systems. In addition to its established applications for the treatment of neurological and psychiatric disorders, and its newly discovered epigenetic mechanisms of action, the peripheral metabolic effects of VPA administration, in particular impinging on the heart and on the liver, are now starting to be understood. These have important consequences for the management of therapy and also for investigation purposes. The aim of this article is on one hand to summarize the emerging knowledge on the role of VPA during the occurrence of cardio-metabolic dysfunctions and on the other hand to describe concisely the VPA-induced epigenetic modifications in target cells.

Author(s): 
Mazzoccoli, Gianluigi
Longhitano, Calogero
Vinciguerra, Manlio
Item Type: 
Journal Article
Publication Title: 
Current Clinical Pharmacology
Journal Abbreviation: 
Curr Clin Pharmacol
Publication Date: 
2014-05
Publication Year: 
2014
Pages: 
165-170
Volume: 
9
Issue: 
2
ISSN: 
2212-3938
Library Catalog: 
PubMed
Extra: 
PMID: 23237609

Turabian/Chicago Citation

Gianluigi Mazzoccoli, Calogero Longhitano and Manlio Vinciguerra. 2014-05. "Cardio-hepatic metabolic derangements and valproic acid." Current Clinical Pharmacology 9: 2: 165-170.

Wikipedia Citation

<ref> {{Cite journal | doi = | issn = 2212-3938 | volume = 9 | pages = 165-170 | last = Mazzoccoli | first = Gianluigi | coauthors = Longhitano, Calogero, Vinciguerra, Manlio | title = Cardio-hepatic metabolic derangements and valproic acid | journal = Current Clinical Pharmacology | date = 2014-05 | pmid = | pmc = }} </ref>