Catechol-O-methyltransferase (COMT) genotype moderates the effects of childhood trauma on cognition and symptoms in schizophrenia
Language: 
English
Abstract: 

The interaction of genetic and environmental factors may affect the course and development of psychotic disorders. We examined whether the effects of childhood trauma on cognition and symptoms in schizophrenia were moderated by the Catechol-O-methyltransferase (COMT) Val(158)Met polymorphism, a common genetic variant known to affect cognition and prefrontal dopamine levels. Participants were 429 schizophrenia/schizoaffective cases from the Australian Schizophrenia Research Bank (ASRB). Cognitive performance was assessed using the Repeatable Battery for Assessment of Neuropsychological Status (RBANS), Controlled Oral Word Association Test (COWAT), Letter Number Sequencing (LNS) test, and the Wechsler Test of Adult Reading (WTAR). Hierarchical regression was used to test the main effects and additive interaction effects of genotype and childhood trauma in the domains of physical abuse, emotional abuse, and emotional neglect, on cognition and symptom profiles of clinical cases. Consistent with previous findings, COMT Val homozygotes performed worse on cognitive measures in the absence of childhood adversity. In addition, a significant interaction between COMT genotype and physical abuse was associated with better executive function in Val homozygotes, relative to those of the same genotype with no history of abuse. Finally, the severity of positive symptoms was greater in Met carriers who had experienced physical abuse, and the severity of negative symptoms in Met carriers was greater in the presence of emotional neglect. These results suggest that the possible epigenetic modulation of the expression of the COMT Val(158)Met polymorphism and consequent effects on cognition and symptoms in schizophrenia, with worse outcomes associated with adverse childhood experiences in Met carriers.

Author(s): 
Green, Melissa J.
Chia, T.-Yunn
Cairns, Murray J.
Wu, Jingqin
Tooney, Paul A.
Scott, Rodney J.
Carr, Vaughan J.
Australian Schizophrenia Research Bank
Item Type: 
Journal Article
Publication Title: 
Journal of Psychiatric Research
Journal Abbreviation: 
J Psychiatr Res
Publication Date: 
2014-02
Publication Year: 
2014
Pages: 
43-50
Volume: 
49
ISSN: 
1879-1379
DOI: 
10.1016/j.jpsychires.2013.10.018
Library Catalog: 
PubMed
Extra: 
PMID: 24252819

Turabian/Chicago Citation

Melissa J. Green, T.-Yunn Chia, Murray J. Cairns, Jingqin Wu, Paul A. Tooney, Rodney J. Scott, Vaughan J. Carr and Australian Schizophrenia Research Bank. 2014-02. "Catechol-O-methyltransferase (COMT) genotype moderates the effects of childhood trauma on cognition and symptoms in schizophrenia." Journal of Psychiatric Research 49: 43-50. 10.1016/j.jpsychires.2013.10.018.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1016/j.jpsychires.2013.10.018 | issn = 1879-1379 | volume = 49 | pages = 43-50 | last = Green | first = Melissa J. | coauthors = Chia, T.-Yunn, Cairns, Murray J., Wu, Jingqin, Tooney, Paul A., Scott, Rodney J., Carr, Vaughan J., Australian Schizophrenia Research Bank | title = Catechol-O-methyltransferase (COMT) genotype moderates the effects of childhood trauma on cognition and symptoms in schizophrenia | journal = Journal of Psychiatric Research | date = 2014-02 | pmid = | pmc = }} </ref>