Cell-nonautonomous signaling of FOXO/DAF-16 to the stem cells of Caenorhabditis elegans
Language: 
English
Abstract: 

In Caenorhabditis elegans (C. elegans), the promotion of longevity by the transcription factor DAF-16 requires reduced insulin/IGF receptor (IIR) signaling or the ablation of the germline, although the reason for the negative impact of germ cells is unknown. FOXO/DAF-16 activity inhibits germline proliferation in both daf-2 mutants and gld-1 tumors. In contrast to its function as a germline tumor suppressor, we now provide evidence that somatic DAF-16 in the presence of IIR signaling can also result in tumorigenic activity, which counteracts robust lifespan extension. In contrast to the cell-autonomous IIR signaling, which is required for larval germline proliferation, activation of DAF-16 in the hypodermis results in hyperplasia of the germline and disruption of the surrounding basement membrane. SHC-1 adaptor protein and AKT-1 kinase antagonize, whereas AKT-2 and SGK-1 kinases promote, this cell-nonautonomous DAF-16 function. Our data suggest that a functional balance of DAF-16 activities in different tissues determines longevity and reveals a novel, cell-nonautonomous role of FOXO/DAF-16 to affect stem cells.

Author(s): 
Qi, Wenjing
Huang, Xu
Neumann-Haefelin, Elke
Schulze, Ekkehard
Baumeister, Ralf
Item Type: 
Journal Article
Publication Title: 
PLoS genetics
Journal Abbreviation: 
PLoS Genet.
Publication Date: 
2012
Publication Year: 
2012
Pages: 
e1002836
Volume: 
8
Issue: 
8
ISSN: 
1553-7404
DOI: 
10.1371/journal.pgen.1002836
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 22916022 PMCID: PMC3420913

Turabian/Chicago Citation

Wenjing Qi, Xu Huang, Elke Neumann-Haefelin, Ekkehard Schulze and Ralf Baumeister. 2012. "Cell-nonautonomous signaling of FOXO/DAF-16 to the stem cells of Caenorhabditis elegans." PLoS genetics 8: 8: e1002836. 10.1371/journal.pgen.1002836.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1371/journal.pgen.1002836 | issn = 1553-7404 | volume = 8 | pages = e1002836 | last = Qi | first = Wenjing | coauthors = Huang, Xu, Neumann-Haefelin, Elke, Schulze, Ekkehard, Baumeister, Ralf | title = Cell-nonautonomous signaling of FOXO/DAF-16 to the stem cells of Caenorhabditis elegans | journal = PLoS genetics | date = 2012 | pmid = | pmc = }} </ref>