Clitoria ternatea ameliorated the intracerebroventricularly injected streptozotocin induced cognitive impairment in rats: behavioral and biochemical evidence
Language: 
English
Short Title: 
Clitoria ternatea ameliorated the intracerebroventricularly injected streptozotocin induced cognitive impairment in rats
Abstract: 

RATIONALE: Clitoria ternatea, commonly known as Aparajita, is used as Medhya rasayana in Ayurveda. The role of C. ternatea in experimental models of cognitive impairment is yet to be explored. OBJECTIVES: The present study was designed to study the effect of aqueous and hydroalcoholic extracts of C. ternatea on biochemical and behavioral parameters related to cognitive impairment in in vitro and in vivo studies. METHODS: In vitro free radical scavenging and enzyme-inhibitory (cholinesterase, glycogen synthase kinase-3-β, rho kinase, prolyl endopeptidase, catechol-O-methyl transferase, and lipoxygenase) activities of aqueous and hydroalcoholic extracts of C. ternatea plant were evaluated. Based on in vitro results, hydroalcoholic extract of C. ternatea (100, 300, and 500 mg/kg, p.o.) was selected for evaluation in intracerebroventricularly injected streptozotocin (STZ)-induced cognitive impairment in male Wistar rats. Behavioral assessment was performed at baseline and on the 14th, 21st, and 28th days after STZ injection using elevated plus maze, passive avoidance, Morris water maze, and photoactometer. Oxidative stress parameters (malondialdehyde, reduced glutathione, nitric oxide levels, and superoxide dismutase activity), cholinesterase activity, and rho kinase (ROCK II) expression were studied in cerebral cortex and hippocampus of rats' brain at the end of the study. RESULTS: The hydroalcoholic extract possessed significantly more in vitro antioxidant and enzyme-inhibitory activities as compared to aqueous extract. The hydroalcoholic extract of C. ternatea prevented STZ-induced cognitive impairment dose dependently by reducing oxidative stress, cholinesterase activity, and ROCK II expression. CONCLUSION: In vitro and in vivo results suggest the potential of hydroalcoholic extract of C. ternatea for treatment of cognitive deficit in neurological disorders.

Author(s): 
Mehla, Jogender
Pahuja, Monika
Gupta, Pooja
Dethe, Shekhar
Agarwal, Amit
Gupta, Yogendra Kumar
Item Type: 
Journal Article
Publication Title: 
Psychopharmacology
Journal Abbreviation: 
Psychopharmacology (Berl.)
Publication Date: 
Dec 2013
Publication Year: 
2013
Pages: 
589-605
Volume: 
230
Issue: 
4
ISSN: 
1432-2072
DOI: 
10.1007/s00213-013-3185-7
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 23832386

Turabian/Chicago Citation

Jogender Mehla, Monika Pahuja, Pooja Gupta, Shekhar Dethe, Amit Agarwal and Yogendra Kumar Gupta. Dec 2013. "Clitoria ternatea ameliorated the intracerebroventricularly injected streptozotocin induced cognitive impairment in rats: behavioral and biochemical evidence." Psychopharmacology 230: 4: 589-605. 10.1007/s00213-013-3185-7.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1007/s00213-013-3185-7 | issn = 1432-2072 | volume = 230 | pages = 589-605 | last = Mehla | first = Jogender | coauthors = Pahuja, Monika, Gupta, Pooja, Dethe, Shekhar, Agarwal, Amit, Gupta, Yogendra Kumar | title = Clitoria ternatea ameliorated the intracerebroventricularly injected streptozotocin induced cognitive impairment in rats: behavioral and biochemical evidence | journal = Psychopharmacology | date = Dec 2013 | pmid = | pmc = }} </ref>