Comparison of enteroprotective efficacy of triphala formulations (Indian Herbal Drug) on methotrexate-induced small intestinal damage in rats
Language: 
English
Abstract: 

Triphala is categorized as a rejuvenator and antioxidant-rich Ayurvedic herbal formulation and has traditionally been used in various gastric problems including intestinal inflammation. The aim of the present study was to examine the comparative enteroprotective effect of Triphala formulations against methotrexate-induced intestinal damage in rats. Triphala formulations were prepared by mixing equal (1:1:1) and unequal (1:2:4) proportions of Terminalia chebula Retz., Terminalia belerica (Gaertn.) Roxb. and Emblica officinalis Gaertn. Intestinal damage was induced by administering methotrexate (MTX) in a dose of 12 mg/kg, orally for 4 days to albino rats. The intestinal damage response was assessed by gross and microscopical injury, measuring the intestinal permeability to phenol red and tissue biochemical parameters. Triphala equal and unequal formulations at the dose of 540 mg/kg significantly restored the depleted protein level in brush border membrane of intestine, phospholipid and glutathione content and decreased the myeloperoxidase and xanthine oxidase level in intestinal mucosa of methotrexate-treated rats. In addition, Triphala unequal formulation showed significant decrease in permeation clearance of phenol red with significant attenuation in the histopathological changes, level of disaccharidase in brush border membrane vesicles and lipid peroxidation content of intestinal mucosa. Based on the data generated, it is suggested that Triphala unequal formulation provides significantly more protection than Triphala equal formulation against methotrexate-induced damage in rat intestine.

Author(s): 
Nariya, Mukeshkumar
Shukla, Vinay
Jain, Sunita
Ravishankar, Basavaiah
Item Type: 
Journal Article
Publication Title: 
Phytotherapy research: PTR
Journal Abbreviation: 
Phytother Res
Publication Date: 
2009-08
Publication Year: 
2009
Pages: 
1092-1098
Volume: 
23
Issue: 
8
ISSN: 
1099-1573
DOI: 
10.1002/ptr.2744
Library Catalog: 
PubMed
Extra: 
PMID: 19170156

Turabian/Chicago Citation

Mukeshkumar Nariya, Vinay Shukla, Sunita Jain and Basavaiah Ravishankar. 2009-08. "Comparison of enteroprotective efficacy of triphala formulations (Indian Herbal Drug) on methotrexate-induced small intestinal damage in rats." Phytotherapy research: PTR 23: 8: 1092-1098. 10.1002/ptr.2744.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1002/ptr.2744 | issn = 1099-1573 | volume = 23 | pages = 1092-1098 | last = Nariya | first = Mukeshkumar | coauthors = Shukla, Vinay, Jain, Sunita, Ravishankar, Basavaiah | title = Comparison of enteroprotective efficacy of triphala formulations (Indian Herbal Drug) on methotrexate-induced small intestinal damage in rats | journal = Phytotherapy research: PTR | date = 2009-08 | pmid = | pmc = }} </ref>