Could Sirt1-mediated epigenetic effects contribute to the longevity response to dietary restriction and be mimicked by other dietary interventions?
Language: 
English
Abstract: 

Dietary restriction (DR) increases lifespan in a range of evolutionarily distinct species. The polyphenol resveratrol may be a dietary mimetic of some effects of DR. The pivotal role of the mammalian histone deacetylase (HDAC) Sirt1, and its homologue in other organisms, in mediating the effects of both DR and resveratrol on lifespan/ageing suggests it may be the common conduit through which these dietary interventions influence ageing. We propose the novel hypothesis that effects of DR relevant to lifespan extension include maintenance of DNA methylation patterns through Sirt1-mediated epigenetic effects, and proffer the view that dietary components, including resveratrol, may mimic these actions.

Author(s): 
Wakeling, Luisa A.
Ions, Laura J.
Ford, Dianne
Item Type: 
Journal Article
Publication Title: 
Age (Dordrecht, Netherlands)
Journal Abbreviation: 
Age (Dordr)
Publication Date: 
2009-12
Publication Year: 
2009
Pages: 
327-341
Volume: 
31
Issue: 
4
ISSN: 
1574-4647
DOI: 
10.1007/s11357-009-9104-5
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 19568959 PMCID: PMC2813047

Turabian/Chicago Citation

Luisa A. Wakeling, Laura J. Ions and Dianne Ford. 2009-12. "Could Sirt1-mediated epigenetic effects contribute to the longevity response to dietary restriction and be mimicked by other dietary interventions?." Age (Dordrecht, Netherlands) 31: 4: 327-341. 10.1007/s11357-009-9104-5.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1007/s11357-009-9104-5 | issn = 1574-4647 | volume = 31 | pages = 327-341 | last = Wakeling | first = Luisa A. | coauthors = Ions, Laura J., Ford, Dianne | title = Could Sirt1-mediated epigenetic effects contribute to the longevity response to dietary restriction and be mimicked by other dietary interventions? | journal = Age (Dordrecht, Netherlands) | date = 2009-12 | pmid = | pmc = }} </ref>