[Cytomegalovirus infection and its possible treatment with herbal medicines]
Language: 
Japanese
Abstract: 

Medicinal herbs, Geum japonicum, Syzygium aromaticum, Terminalia chebula, and Rhus javanica, with anti-herpes simplex virus therapeutic activity, inhibited replication of human cytomegalovirus(CMV) and murine CMV(MCMV) in vitro. These anti-CMV activities were examined in an MCMV infection model using immunosuppressed mice. Geum japonicum, Syzygium aromaticum, and Terminalia chebula significantly suppressed MCMV yields in lungs of treated mice compared with water treatment. Efficacy of oral treatment with 750 mg/kg/day of Geum japonicum-extract was similar to that of the intraperitoneal administration with 2 mg/kg/day of ganciclovir in increasing the body weight of infected mice and reducing the virus yield in the lungs. These herbs may be beneficial for the prophylaxis of CMV diseases in immunocompromized patients.

Author(s): 
Shiraki, K.
Yukawa, T.
Kurokawa, M.
Kageyama, S.
Item Type: 
Journal Article
Publication Title: 
Nihon Rinsho. Japanese Journal of Clinical Medicine
Journal Abbreviation: 
Nippon Rinsho
Publication Date: 
1998-01
Publication Year: 
1998
Pages: 
156-160
Volume: 
56
Issue: 
1
ISSN: 
0047-1852
Library Catalog: 
PubMed
Extra: 
PMID: 9465682

Turabian/Chicago Citation

K. Shiraki, T. Yukawa, M. Kurokawa and S. Kageyama. 1998-01. "[Cytomegalovirus infection and its possible treatment with herbal medicines]." Nihon Rinsho. Japanese Journal of Clinical Medicine 56: 1: 156-160.

Wikipedia Citation

<ref> {{Cite journal | doi = | issn = 0047-1852 | volume = 56 | pages = 156-160 | last = Shiraki | first = K. | coauthors = Yukawa, T., Kurokawa, M., Kageyama, S. | title = [Cytomegalovirus infection and its possible treatment with herbal medicines] | journal = Nihon Rinsho. Japanese Journal of Clinical Medicine | date = 1998-01 | pmid = | pmc = }} </ref>