delta-Opioid receptors protect from anoxic disruption of Na+ homeostasis via Na+ channel regulation
Language: 
English
Abstract: 

Hypoxic/ischemic disruption of ionic homeostasis is a critical trigger of neuronal injury/death in the brain. There is, however, no promising strategy against such pathophysiologic change to protect the brain from hypoxic/ischemic injury. Here, we present a novel finding that activation of delta-opioid receptors (DOR) reduced anoxic Na+ influx in the mouse cortex, which was completely blocked by DOR antagonism with naltrindole. Furthermore, we co-expressed DOR and Na+ channels in Xenopus oocytes and showed that DOR expression and activation indeed play an inhibitory role in Na+ channel regulation by decreasing the amplitude of sodium currents and increasing activation threshold of Na+ channels. Our results suggest that DOR protects from anoxic disruption of Na+ homeostasis via Na+ channel regulation. These data may potentially have significant impacts on understanding the intrinsic mechanism of neuronal responses to stress and provide clues for better solutions of hypoxic/ischemic encephalopathy, and for the exploration of acupuncture mechanism since acupuncture activates opioid system.

Author(s): 
Kang, Xuezhi
Chao, Dongman
Gu, Quanbao
Ding, Guanghong
Wang, Yingwei
Balboni, Gianfranco
Lazarus, Lawrence H.
Xia, Ying
Item Type: 
Journal Article
Publication Title: 
Cellular and molecular life sciences: CMLS
Journal Abbreviation: 
Cell. Mol. Life Sci.
Publication Date: 
Nov 2009
Publication Year: 
2009
Pages: 
3505-3516
Volume: 
66
Issue: 
21
ISSN: 
1420-9071
DOI: 
10.1007/s00018-009-0136-x
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 19756387 PMCID: PMC3061309

Turabian/Chicago Citation

Xuezhi Kang, Dongman Chao, Quanbao Gu, Guanghong Ding, Yingwei Wang, Gianfranco Balboni, Lawrence H. Lazarus and Ying Xia. Nov 2009. "delta-Opioid receptors protect from anoxic disruption of Na+ homeostasis via Na+ channel regulation." Cellular and molecular life sciences: CMLS 66: 21: 3505-3516. 10.1007/s00018-009-0136-x.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1007/s00018-009-0136-x | issn = 1420-9071 | volume = 66 | pages = 3505-3516 | last = Kang | first = Xuezhi | coauthors = Chao, Dongman, Gu, Quanbao, Ding, Guanghong, Wang, Yingwei, Balboni, Gianfranco, Lazarus, Lawrence H., Xia, Ying | title = delta-Opioid receptors protect from anoxic disruption of Na+ homeostasis via Na+ channel regulation | journal = Cellular and molecular life sciences: CMLS | date = Nov 2009 | pmid = | pmc = }} </ref>