Dietary restriction and aging, 2009
Language: 
English
Abstract: 

Dietary restriction (DR) is a robust nongenetic, nonpharmacological intervention that is known to increase active and healthy lifespan in a variety of species. Despite a variety of differences in the protocols and the way DR is carried out in different species, conserved relationships are emerging among multiple species. 2009 saw the field of DR mature with important mechanistic insights from multiple species. A report of lifespan extension in rapamycin-treated mice suggested that the TOR pathway, a conserved mediator of DR in invertebrates, may also be critical to DR effects in mammals. 2009 also saw exciting discoveries related to DR in various organisms including yeast, worms, flies, mice, monkeys and humans. These studies complement each other and together aim to deliver the promise of postponing aging and age-related diseases by revealing the underlying mechanisms of the protective effects of DR. Here, we summarize a few of the reports published in 2009 that we believe provide novel directions and an improved understanding of dietary restriction.

Author(s): 
Katewa, Subhash D.
Kapahi, Pankaj
Item Type: 
Journal Article
Publication Title: 
Aging Cell
Journal Abbreviation: 
Aging Cell
Publication Date: 
2010-04
Publication Year: 
2010
Pages: 
105-112
Volume: 
9
Issue: 
2
ISSN: 
1474-9726
DOI: 
10.1111/j.1474-9726.2010.00552.x
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 20096035 PMCID: PMC2958258

Turabian/Chicago Citation

Subhash D. Katewa and Pankaj Kapahi. 2010-04. "Dietary restriction and aging, 2009." Aging Cell 9: 2: 105-112. 10.1111/j.1474-9726.2010.00552.x.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1111/j.1474-9726.2010.00552.x | issn = 1474-9726 | volume = 9 | pages = 105-112 | last = Katewa | first = Subhash D. | coauthors = Kapahi, Pankaj | title = Dietary restriction and aging, 2009 | journal = Aging Cell | date = 2010-04 | pmid = | pmc = }} </ref>