DRE-1/FBXO11-dependent degradation of BLMP-1/BLIMP-1 governs C. elegans developmental timing and maturation
Language: 
English
Abstract: 

Developmental timing genes catalyze stem cell progression and animal maturation programs across taxa. Caenorhabditis elegans DRE-1/FBXO11 functions in an SCF E3-ubiquitin ligase complex to regulate the transition to adult programs, but its cognate proteolytic substrates are unknown. Here, we identify the conserved transcription factor BLMP-1 as a substrate of the SCF(DRE-1/FBXO11) complex. blmp-1 deletion suppressed dre-1 mutant phenotypes and exhibited developmental timing defects opposite to dre-1. blmp-1 also opposed dre-1 for other life history traits, including entry into the dauer diapause and longevity. BLMP-1 protein was strikingly elevated upon dre-1 depletion and dysregulated in a stage- and tissue-specific manner. The role of DRE-1 in regulating BLMP-1 stability is evolutionary conserved, as†we observed direct protein interaction and degradation function for worm and human counterparts. Taken together, posttranslational regulation of†BLMP-1/BLIMP-1 by DRE-1/FBXO11 coordinates C.†elegans developmental timing and other life history traits, suggesting that this two-protein module mediates metazoan maturation processes.

Author(s): 
Horn, Moritz
Geisen, Christoph
Cermak, Lukas
Becker, Ben
Nakamura, Shuhei
Klein, Corinna
Pagano, Michele
Antebi, Adam
Item Type: 
Journal Article
Publication Title: 
Developmental Cell
Journal Abbreviation: 
Dev. Cell
Publication Date: 
3/31/2014
Publication Year: 
2014
Pages: 
697-710
Volume: 
28
Issue: 
6
ISSN: 
1878-1551
DOI: 
10.1016/j.devcel.2014.01.028
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 24613396 PMCID: PMC4040421

Turabian/Chicago Citation

Moritz Horn, Christoph Geisen, Lukas Cermak, Ben Becker, Shuhei Nakamura, Corinna Klein, Michele Pagano and Adam Antebi. 3/31/2014. "DRE-1/FBXO11-dependent degradation of BLMP-1/BLIMP-1 governs C. elegans developmental timing and maturation." Developmental Cell 28: 6: 697-710. 10.1016/j.devcel.2014.01.028.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1016/j.devcel.2014.01.028 | issn = 1878-1551 | volume = 28 | pages = 697-710 | last = Horn | first = Moritz | coauthors = Geisen, Christoph, Cermak, Lukas, Becker, Ben, Nakamura, Shuhei, Klein, Corinna, Pagano, Michele, Antebi, Adam | title = DRE-1/FBXO11-dependent degradation of BLMP-1/BLIMP-1 governs C. elegans developmental timing and maturation | journal = Developmental Cell | date = 3/31/2014 | pmid = | pmc = }} </ref>