Effect of T. chebula on mitochondrial alterations in experimental myocardial injury
Language: 
English
Abstract: 

Mitochondria play a central role in molecular events leading to tissue damage in ischemia. The present study examines the role of the alcoholic extract of T. chebula (TCE) pretreatment (50 mg/100 g body weight) to attenuate the isoproterenol (ISO) (20mg/100g body wt, sc) induced alterations on heart mitochondrial ultrastucture and function in experimental rats. ISO induced cardiotoxicity was evidenced by a significant rise in the level of lactate, decrease in enzyme activities of tricarboxylic acid cycle (TCA), mitochondrial respiration, levels of adenosine triphosphate (ATP) and oxidative phosphorylation. TCE intervention significantly attenuated the above alterations by ISO and retained near normal function of the mitochondria. Electron microscopic studies of the mitochondria further support the isoproterenol induced deleterious changes and accredit the protective effect of TCE on mitochondrial structure and energy metabolism.

Author(s): 
Suchalatha, Subramaniyan
Srinivasan, Periasamy
Devi, Chennam Srinivasulu Shyamala
Item Type: 
Journal Article
Publication Title: 
Chemico-Biological Interactions
Journal Abbreviation: 
Chem. Biol. Interact.
Publication Date: 
9/20/2007
Publication Year: 
2007
Pages: 
145-153
Volume: 
169
Issue: 
3
ISSN: 
0009-2797
DOI: 
10.1016/j.cbi.2007.06.034
Library Catalog: 
PubMed
Extra: 
PMID: 17678884

Turabian/Chicago Citation

Subramaniyan Suchalatha, Periasamy Srinivasan and Chennam Srinivasulu Shyamala Devi. 9/20/2007. "Effect of T. chebula on mitochondrial alterations in experimental myocardial injury." Chemico-Biological Interactions 169: 3: 145-153. 10.1016/j.cbi.2007.06.034.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1016/j.cbi.2007.06.034 | issn = 0009-2797 | volume = 169 | pages = 145-153 | last = Suchalatha | first = Subramaniyan | coauthors = Srinivasan, Periasamy, Devi, Chennam Srinivasulu Shyamala | title = Effect of T. chebula on mitochondrial alterations in experimental myocardial injury | journal = Chemico-Biological Interactions | date = 9/20/2007 | pmid = | pmc = }} </ref>