Evaluation of the antioxidant effects of four main theaflavin derivatives through chemiluminescence and DNA damage analyses
Language: 
English
Abstract: 

Theaflavins (TFs) are the dimers of a couple of epimerized catechins, which are specially formed during black tea fermentation. To explore the differences among four main TF derivatives (theaflavin (TF(1)), theaflavin-3-gallate (TF(2)A), theaflavin-3'-gallate (TF(2)B), and theaflavin-3,3'-digallate (TF(3))) in scavenging reactive oxygen species (ROS) in vitro, their properties of inhibiting superoxide, singlet oxygen, hydrogen peroxide, and the hydroxyl radical, and their effects on hydroxyl radical-induced DNA oxidative damage were systematically analyzed in the present study. The results show that, compared with (-)-epigallocatechin gallate (EGCG), TF derivatives were good antioxidants for scavenging ROS and preventing the hydroxyl radical-induced DNA damage in vitro. TF(3) was the most positive in scavenging hydrogen peroxide and hydroxyl radical, and TF(1) suppressed superoxide. Positive antioxidant capacities of TF(2)B on singlet oxygen, hydrogen peroxide, hydroxyl radical, and the hydroxyl radical-induced DNA damage in vitro were found. The differences between the antioxidant capacities of four main TF derivatives in relation to their chemical structures were also discussed. We suggest that these activity differences among TF derivatives would be beneficial to scavenge different ROS with therapeutic potential.

Author(s): 
Wu, Yuan-Yuan
Li, Wei
Xu, Yi
Jin, En-hui
Tu, You-ying
Item Type: 
Journal Article
Publication Title: 
Journal of Zhejiang University. Science. B
Journal Abbreviation: 
J Zhejiang Univ Sci B
Publication Date: 
9/11/2015
Publication Year: 
2011
Pages: 
744-751
Volume: 
12
Issue: 
9
ISSN: 
1862-1783
DOI: 
10.1631/jzus.B1100041
Library Catalog: 
PubMed
Extra: 
PMID: 21887850 PMCID: PMC3167908

Turabian/Chicago Citation

Yuan-Yuan Wu, Wei Li, Yi Xu, En-hui Jin and You-ying Tu. 9/11/2015. "Evaluation of the antioxidant effects of four main theaflavin derivatives through chemiluminescence and DNA damage analyses." Journal of Zhejiang University. Science. B 12: 9: 744-751. 10.1631/jzus.B1100041.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1631/jzus.B1100041 | issn = 1862-1783 | volume = 12 | pages = 744-751 | last = Wu | first = Yuan-Yuan | coauthors = Li, Wei, Xu, Yi, Jin, En-hui, Tu, You-ying | title = Evaluation of the antioxidant effects of four main theaflavin derivatives through chemiluminescence and DNA damage analyses | journal = Journal of Zhejiang University. Science. B | date = 9/11/2015 | pmid = | pmc = }} </ref>