Extract from Terminalia chebula seeds protect against experimental ischemic neuronal damage via maintaining SODs and BDNF levels
Language: 
English
Abstract: 

The fruit of Terminalia chebula Retz has been used as a traditional medicine in Asia and contains tannic acid, chebulagic acid, chebulinic acid and corilagin. Extract from T. chebula seeds (TCE) has various biological functions. We observed the neuroprotective effects of TCE against ischemic damage in the hippocampal C1 region (CA1) of the gerbil that had received oral administrations of TCE (100 mg/kg) once a day for 7 days before the induction of transient cerebral ischemia. In the TCE-treated ischemia group, neuronal neuclei (a marker for neurons)-positive neurons were distinctively abundant (62% of the sham group) in the CA1 4 days after ischemia-reperfusion (I-R) compared to those (12.2% of the sham group) in the vehicle-treated ischemia group. Four days after I-R TCE treatment markedly decreased the activation of astrocytes and microglia in the ischemic CA1 compared with the vehicle-treated ischemia group. In addition, immunoreactivities of Cu, Zn-superoxide dismutase (SOD1), Mn-superoxide dismutase (SOD2) and brain-derived neurotrophic factor (BDNF) in the CA1 of the TCE-treated ischemia group were much higher than those in the vehicle-ischemia group 4 days after I-R. Protein levels of SOD1, SOD2 and BDNF in the TCE-treated ischemia group were also much higher than those in the vehicle-ischemia group 4 days after I-R. These results indicate that the repeated supplement of TCE protected neurons from ischemic damage induced by transient cerebral ischemia by maintaining SODs and BDNF levels as well as decreasing glial activation.

Author(s): 
Park, Joon Ha
Joo, Han Seung
Yoo, Ki-Yeon
Shin, Bich Na
Kim, In Hye
Lee, Choong Hyun
Choi, Jung Hoon
Byun, Kyunghee
Lee, Bonghee
Lim, Soon Sung
Kim, Myong Jo
Won, Moo-Ho
Item Type: 
Journal Article
Publication Title: 
Neurochemical Research
Journal Abbreviation: 
Neurochem. Res.
Publication Date: 
2011-11
Publication Year: 
2011
Pages: 
2043-2050
Volume: 
36
Issue: 
11
ISSN: 
1573-6903
DOI: 
10.1007/s11064-011-0528-9
Library Catalog: 
PubMed
Extra: 
PMID: 21667226

Turabian/Chicago Citation

Joon Ha Park, Han Seung Joo, Ki-Yeon Yoo, Bich Na Shin, In Hye Kim, Choong Hyun Lee, Jung Hoon Choi, Kyunghee Byun, Bonghee Lee, Soon Sung Lim, Myong Jo Kim and Moo-Ho Won. 2011-11. "Extract from Terminalia chebula seeds protect against experimental ischemic neuronal damage via maintaining SODs and BDNF levels." Neurochemical Research 36: 11: 2043-2050. 10.1007/s11064-011-0528-9.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1007/s11064-011-0528-9 | issn = 1573-6903 | volume = 36 | pages = 2043-2050 | last = Park | first = Joon Ha | coauthors = Joo, Han Seung, Yoo, Ki-Yeon, Shin, Bich Na, Kim, In Hye, Lee, Choong Hyun, Choi, Jung Hoon, Byun, Kyunghee, Lee, Bonghee, Lim, Soon Sung, Kim, Myong Jo, Won, Moo-Ho | title = Extract from Terminalia chebula seeds protect against experimental ischemic neuronal damage via maintaining SODs and BDNF levels | journal = Neurochemical Research | date = 2011-11 | pmid = | pmc = }} </ref>