Healthy aging: what can we learn from Caenorhabditis elegans?
Language: 
English
Short Title: 
Healthy aging
Abstract: 

The microscopic worm Caenorhabditis elegans (C.†elegans) is one of the most prominent animal models for aging studies. This is underscored by the fact that most of the genes and interventions that modulate the aging process, such as the insulin/IGF pathway, caloric restriction and mitochondrial signalling, were first identified in this organism. Remarkably, many features of the mammalian aging process are recapitulated in C.†elegans: over time, damage to macromolecule accumulates, structural cellular components progressively deteriorate, physiological functions decline, resistance to stress and infections decreases, while morbidity and mortality rates increase. In humans, age represents risk factor number one for most diseases ultimately leading to death in industrialized countries, namely cardiovascular diseases, cancer and neurodegenerative disorders. Genes regulating aging in C.†elegans are evolutionarily conserved and their deregulation is often involved in the development of age-associated diseases in humans. It is therefore likely that any intervention that extends C.†elegans lifespan will indicate strategies to positively impact on healthy human longevity.

Author(s): 
Torgovnick, A.
Schiavi, A.
Maglioni, S.
Ventura, N.
Item Type: 
Journal Article
Publication Title: 
Zeitschrift F¸r Gerontologie Und Geriatrie
Journal Abbreviation: 
Z Gerontol Geriatr
Publication Date: 
2013-10
Publication Year: 
2013
Pages: 
623-628
Volume: 
46
Issue: 
7
ISSN: 
1435-1269
DOI: 
10.1007/s00391-013-0533-5
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 23949012

Turabian/Chicago Citation

A. Torgovnick, A. Schiavi, S. Maglioni and N. Ventura. 2013-10. "Healthy aging: what can we learn from Caenorhabditis elegans?." Zeitschrift F¸r Gerontologie Und Geriatrie 46: 7: 623-628. 10.1007/s00391-013-0533-5.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1007/s00391-013-0533-5 | issn = 1435-1269 | volume = 46 | pages = 623-628 | last = Torgovnick | first = A. | coauthors = Schiavi, A., Maglioni, S., Ventura, N. | title = Healthy aging: what can we learn from Caenorhabditis elegans? | journal = Zeitschrift F¸r Gerontologie Und Geriatrie | date = 2013-10 | pmid = | pmc = }} </ref>