Mechanisms underlying the effect of acupuncture on cognitive improvement: a systematic review of animal studies
Language: 
English
Short Title: 
Mechanisms underlying the effect of acupuncture on cognitive improvement
Abstract: 

Acupuncture has been reported to be beneficial in treating cognitive impairment in various pathological conditions. This review describes the effort to understand the signaling pathways that underlie the acupunctural therapeutic effect on cognitive function. We searched the literature in 12 electronic databases from their inception to November 2013, with full text available and language limited to English. Twenty-three studies were identified under the selection criteria. All recruited animal studies demonstrate a significant positive effect of acupuncture on cognitive impairment. Findings suggest acupuncture may improve cognitive function through modulation of signaling pathways involved in neuronal survival and function, specifically, through promoting cholinergic neural transmission, facilitating dopaminergic synaptic transmission, enhancing neurotrophin signaling, suppressing oxidative stress, attenuating apoptosis, regulating glycometabolic enzymes and reducing microglial activation. However, the quality of reviewed studies has room for improvement. Further high-quality animal studies with randomization, blinding and estimation of sample size are needed to strengthen the recognition of group differences.

Author(s): 
Leung, Mason Chin Pang
Yip, Ka Keung
Ho, Yuen Shan
Siu, Flora Ka Wai
Li, Wai Chin
Garner, Belinda
Item Type: 
Journal Article
Publication Title: 
Journal of Neuroimmune Pharmacology: The Official Journal of the Society on NeuroImmune Pharmacology
Journal Abbreviation: 
J Neuroimmune Pharmacol
Publication Date: 
2014-09
Publication Year: 
2014
Pages: 
492-507
Volume: 
9
Issue: 
4
ISSN: 
1557-1904
DOI: 
10.1007/s11481-014-9550-4
Library Catalog: 
PubMed
Extra: 
PMID: 24903518

Turabian/Chicago Citation

Mason Chin Pang Leung, Ka Keung Yip, Yuen Shan Ho, Flora Ka Wai Siu, Wai Chin Li and Belinda Garner. 2014-09. "Mechanisms underlying the effect of acupuncture on cognitive improvement: a systematic review of animal studies." Journal of Neuroimmune Pharmacology: The Official Journal of the Society on NeuroImmune Pharmacology 9: 4: 492-507. 10.1007/s11481-014-9550-4.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1007/s11481-014-9550-4 | issn = 1557-1904 | volume = 9 | pages = 492-507 | last = Leung | first = Mason Chin Pang | coauthors = Yip, Ka Keung, Ho, Yuen Shan, Siu, Flora Ka Wai, Li, Wai Chin, Garner, Belinda | title = Mechanisms underlying the effect of acupuncture on cognitive improvement: a systematic review of animal studies | journal = Journal of Neuroimmune Pharmacology: The Official Journal of the Society on NeuroImmune Pharmacology | date = 2014-09 | pmid = | pmc = }} </ref>