Meta?analysis of genetic variants associated with human exceptional longevity

Despite evidence from family studies that there is a strong genetic influence upon exceptional longevity, relatively few genetic variants have been associated with this trait. One reason could be that many genes individually have such weak effects that they cannot meet standard thresholds of genome wide significance, but as a group in specific combinations of genetic variations, they can have a strong influence. Previously we reported that such genetic signatures of 281 genetic markers associated with about 130 genes can do a relatively good job of differentiating centenarians from non?centenarians particularly if the centenarians are 106 years and older. This would support our hypothesis that the genetic influence upon exceptional longevity increases with older and older (and rarer) ages. We investigated this list of markers using similar genetic data from 5 studies of centenarians from the USA, Europe and Japan. The results from the meta?analysis show that many of these variants are associated with survival to these extreme ages in other studies. Since many centenarians compress morbidity and disability towards the end of their lives, these results could point to biological pathways and therefore new therapeutics to increase years of healthy lives in the general population.

Sebastiani, Paola
Bae, Harold
Sun, Fangui X.
Andersen, Stacy L.
Daw, E. Warwick
Malovini, Alberto
Kojima, Toshio
Hirose, Nobuyoshi
Schupf, Nicole
Puca, Annibale
Perls, Thomas T.
Item Type: 
Journal Article
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Journal Abbreviation: 
Aging (Albany NY)
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Library Catalog: 
NCBI Published Medical (?)
PMID: 24244950 PMCID: PMC3808698

Turabian/Chicago Citation

Paola Sebastiani, Harold Bae, Fangui X. Sun, Stacy L. Andersen, E. Warwick Daw, Alberto Malovini, Toshio Kojima, Nobuyoshi Hirose, Nicole Schupf, Annibale Puca and Thomas T. Perls. 2013-09. "Meta?analysis of genetic variants associated with human exceptional longevity." Aging 5: 9: 653-661.

Wikipedia Citation

<ref> {{Cite journal | doi = | issn = 1945-4589 | volume = 5 | pages = 653-661 | last = Sebastiani | first = Paola | coauthors = Bae, Harold, Sun, Fangui X., Andersen, Stacy L., Daw, E. Warwick, Malovini, Alberto, Kojima, Toshio, Hirose, Nobuyoshi, Schupf, Nicole, Puca, Annibale, Perls, Thomas T. | title = Meta?analysis of genetic variants associated with human exceptional longevity | journal = Aging | date = 2013-09 | pmid = | pmc = }} </ref>