Mindfulness-based stress reduction (MBSR) as sole intervention for non-somatisation chronic non-cancer pain (CNCP): protocol for a systematic review and meta-analysis of randomised controlled trials
Language: 
English
Short Title: 
Mindfulness-based stress reduction (MBSR) as sole intervention for non-somatisation chronic non-cancer pain (CNCP)
Abstract: 

INTRODUCTION: Chronic non-cancer pain (CNCP) affects up to 50% of the world's population. It impacts negatively on quality of life; entailing high costs on our medical systems, and translates to economic burden due to work loss. Aetiology of CNCP is complex and multifactorial, embracing the somatosensory, cognitive and affective domains. Opioid analgesia and other invasive interventions are often inadequate for clinical management of CNCP. Recently, mindfulness-based stress reduction (MBSR) has become a popular therapy for various medical conditions, including CNCP. However, studies reported varying efficacies, and relevant systematic reviews have included clinical trials with inherent heterogeneity either in study conditions or types of interventions used. Our study aims to provide an updated and more critical evaluation of the efficacy of MBSR as the intervention for non-somatisation CNCP. METHODS AND ANALYSIS: A systematic review with meta-analysis of randomised controlled trials published in English will be performed in accordance with the Preferred Reporting Items for Systematic reviews and Meta-analyses (PRISMA) guidelines and the Cochrane Collaboration format. MEDLINE, EMBASE, PsychINFO, and the Cochrane Central Register of Controlled Trials Intervention, will be searched independently by reviewers using defined MeSH terms. Studies with full texts using MBSR as the main intervention on patients with non-somatising CNCP will be included. Outcome measures include pain scores and disability assessment scales. Continuous data will be meta-analysed using the RevMan 5 Review Manager programme. Primary analysis will adopt the random effects model in view of heterogeneity between trials. The standardised mean difference will be expressed as the effect size with 95% CIs. Forest plots, funnel plots, the I(2) statistic and the Cochrane Risks of Bias Assessment table will be included. ETHICS AND DISSEMINATION: No ethics approval is deemed necessary. Results of this study will be disseminated via peer-reviewed publications and scientific meetings. TRIALS REGISTRATION NUMBER: PROSPERO CRD42014015568.

Author(s): 
Leung, Lawrence
Han, Han
Martin, Mary
Kotecha, Jyoti
Item Type: 
Journal Article
Publication Title: 
BMJ open
Journal Abbreviation: 
BMJ Open
Publication Date: 
5/18/2015
Publication Year: 
2015
Pages: 
e007650
Volume: 
5
Issue: 
5
ISSN: 
2044-6055
DOI: 
10.1136/bmjopen-2015-007650
Library Catalog: 
PubMed
Extra: 
PMID: 25986638 PMCID: PMC4442214

Turabian/Chicago Citation

Lawrence Leung, Han Han, Mary Martin and Jyoti Kotecha. 5/18/2015. "Mindfulness-based stress reduction (MBSR) as sole intervention for non-somatisation chronic non-cancer pain (CNCP): protocol for a systematic review and meta-analysis of randomised controlled trials." BMJ open 5: 5: e007650. 10.1136/bmjopen-2015-007650.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1136/bmjopen-2015-007650 | issn = 2044-6055 | volume = 5 | pages = e007650 | last = Leung | first = Lawrence | coauthors = Han, Han, Martin, Mary, Kotecha, Jyoti | title = Mindfulness-based stress reduction (MBSR) as sole intervention for non-somatisation chronic non-cancer pain (CNCP): protocol for a systematic review and meta-analysis of randomised controlled trials | journal = BMJ open | date = 5/18/2015 | pmid = | pmc = }} </ref>