Protective effect of Triphala on cold stress-induced behavioral and biochemical abnormalities in rats
Language: 
English
Abstract: 

Stress is one of the basic factors in the etiology of number of diseases. Cold-stress occurs when the surrounding temperature drops below 18 degrees C, the body may not be able to warm itself, and hence serious cold-related illnesses, permanent tissue damage and death may results. The present study was aimed to investigate the effect of Triphala (Terminalia chebula, Terminalia belerica and Emblica officinalis) against the cold stress-induced alterations in the behavioral and biochemical abnormalities in four different groups (saline control, Triphala, cold-stress and Triphala with cold-stress) of Wistar strain albino rats. In this study cold-stress (8 degrees C for 16 h/d/15 days) was applied and the oxidative stress was assessed by measuring the extent of lipid peroxidation (LPO) and the changes in corticosterone levels. Upon exposure to the cold-stress, a significant (P<0.05) increase in immobilization with decrease in rearing, grooming, and ambulation behavior was seen in open field. Following cold-exposure, significant increase in the LPO and corticosterone levels was observed. Oral administration of Triphala (1 g/kg/animal body weight) for 48 days significantly prevented these cold stress-induced behavioral and biochemical abnormalities in albino rats. The results of this study suggest that Triphala supplementation can be regarded as a protective drug against stress.

Author(s): 
Dhanalakshmi, Selvakumar
Devi, Rathinasamy Sheela
Srikumar, Ramasundaram
Manikandan, Sundaramahalingam
Thangaraj, Ramasundaram
Item Type: 
Journal Article
Publication Title: 
Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
Journal Abbreviation: 
Yakugaku Zasshi
Publication Date: 
2007-11
Publication Year: 
2007
Pages: 
1863-1867
Volume: 
127
Issue: 
11
ISSN: 
0031-6903
Library Catalog: 
PubMed
Extra: 
PMID: 17978562

Turabian/Chicago Citation

Selvakumar Dhanalakshmi, Rathinasamy Sheela Devi, Ramasundaram Srikumar, Sundaramahalingam Manikandan and Ramasundaram Thangaraj. 2007-11. "Protective effect of Triphala on cold stress-induced behavioral and biochemical abnormalities in rats." Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan 127: 11: 1863-1867.

Wikipedia Citation

<ref> {{Cite journal | doi = | issn = 0031-6903 | volume = 127 | pages = 1863-1867 | last = Dhanalakshmi | first = Selvakumar | coauthors = Devi, Rathinasamy Sheela, Srikumar, Ramasundaram, Manikandan, Sundaramahalingam, Thangaraj, Ramasundaram | title = Protective effect of Triphala on cold stress-induced behavioral and biochemical abnormalities in rats | journal = Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan | date = 2007-11 | pmid = | pmc = }} </ref>