Recent advances in postmortem pathology and neurochemistry in schizophrenia
Language: 
English
Abstract: 

PURPOSE OF REVIEW: This is a review examining recent data from the study of the postmortem central nervous system (CNS) of patients with schizophrenia. RECENT FINDINGS: Studies on the human CNS transcriptome suggest changes in pro-inflammatory pathways and myelination in schizophrenia, whereas changes in the proteome suggest that pathways involved in energy and metabolism may be particularly stressed. There appear to be complex changes in the expression of proposed candidate genes for schizophrenia such as NRG1, DISC1, RGS4 and DTNB1, and there are continued reports of alterations in central gamma-aminobutyric acidergic, dopaminergic, glutamatergic and cholinergic pathways in patients with the disorder. Data on epigenetic mechanisms and transcriptome regulation suggest that at least some changes in gene expression may be due to changes in levels of gene promoter methylation or microRNAs in the CNS of patients with schizophrenia. SUMMARY: Postmortem CNS studies have begun to unravel changes in the epigenetic regulation of gene expression that may be central to how gene-environment interactions contribute to the onset of schizophrenia. In addition, a recent study indicates that it is possible to use biomarkers to segregate the syndrome of schizophrenia into more biologically homogeneous populations, which should decrease the biological complexity observed within that group within the schizophrenia syndrome.

Author(s): 
Dean, Brian
Boer, Simone
Gibbons, Andrew
Money, Tammie
Scarr, Elizabeth
Item Type: 
Journal Article
Publication Title: 
Current Opinion in Psychiatry
Journal Abbreviation: 
Curr Opin Psychiatry
Publication Date: 
2009-03
Publication Year: 
2009
Pages: 
154-160
Volume: 
22
Issue: 
2
ISSN: 
1473-6578
DOI: 
10.1097/YCO.0b013e328323d52e
Library Catalog: 
PubMed
Extra: 
PMID: 19553869

Turabian/Chicago Citation

Brian Dean, Simone Boer, Andrew Gibbons, Tammie Money and Elizabeth Scarr. 2009-03. "Recent advances in postmortem pathology and neurochemistry in schizophrenia." Current Opinion in Psychiatry 22: 2: 154-160. 10.1097/YCO.0b013e328323d52e.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1097/YCO.0b013e328323d52e | issn = 1473-6578 | volume = 22 | pages = 154-160 | last = Dean | first = Brian | coauthors = Boer, Simone, Gibbons, Andrew, Money, Tammie, Scarr, Elizabeth | title = Recent advances in postmortem pathology and neurochemistry in schizophrenia | journal = Current Opinion in Psychiatry | date = 2009-03 | pmid = | pmc = }} </ref>