[S-adenosyl L-methionine in CNS diseases]
Language: 
Polish
Abstract: 

S-adenosyl L-methionine (SAMe) is the natural, universal methyl group donor, participating in transmethylation reactions, known and commonly used as a dietary supplement since 1952. It plays an important role in the synthesis of neuromediators and melatonin and mechanisms of epigenetic regulation. The aim of this article is to review the literature about possibilities of SAMe application in the therapy of CNS diseases: depression, dementia syndromes, schizophrenia and somatic disorders. SAMe is the promising dietary supplement, which may be successfully used as a substance increasing effectiveness of the treatment of depression, with antidepressants in monotherapy in mild depressive states or depressive symptoms. SAMe addition to antipsychotic drug, may lead to the improvement of the quality of life and reduction of aggressiveness of patients. SAMe may be an effective substance in the therapy and prophylaxis of mild cognitive impairments and mild dementia syndrome. SAMe possesses some hepatoprotective action, so it may decrease the risk of the development of neoplasm, alcohol-induced liver disease (ALD) and cirrhosis. SAMe improves the functions of joints and decreases the experience of pain in rheumatoid arthritis (RA).

Author(s): 
Krzystanek, Marek
Pa?asz, Artur
Krzystanek, Ewa
Krupka-Matuszczyk, Irea
Wiaderkiewicz, Ryszard
Skowronek, Rafa?
Item Type: 
Journal Article
Publication Title: 
Psychiatria Polska
Journal Abbreviation: 
Psychiatr. Pol.
Publication Date: 
2011-12
Publication Year: 
2011
Pages: 
923-931
Volume: 
45
Issue: 
6
ISSN: 
0033-2674
Library Catalog: 
PubMed
Extra: 
PMID: 22335134

Turabian/Chicago Citation

Marek Krzystanek, Artur Pa?asz, Ewa Krzystanek, Irea Krupka-Matuszczyk, Ryszard Wiaderkiewicz and Rafa? Skowronek. 2011-12. "[S-adenosyl L-methionine in CNS diseases]." Psychiatria Polska 45: 6: 923-931.

Wikipedia Citation

<ref> {{Cite journal | doi = | issn = 0033-2674 | volume = 45 | pages = 923-931 | last = Krzystanek | first = Marek | coauthors = Pa?asz, Artur, Krzystanek, Ewa, Krupka-Matuszczyk, Irea, Wiaderkiewicz, Ryszard, Skowronek, Rafa? | title = [S-adenosyl L-methionine in CNS diseases] | journal = Psychiatria Polska | date = 2011-12 | pmid = | pmc = }} </ref>