Sumoylation of critical proteins in amyotrophic lateral sclerosis: emerging pathways of pathogenesis
Language: 
English
Short Title: 
Sumoylation of critical proteins in amyotrophic lateral sclerosis
Abstract: 

Emerging lines of evidence suggest a relationship between amyotrophic lateral sclerosis (ALS) and protein sumoylation. Multiple studies have demonstrated that several of the proteins involved in the pathogenesis of ALS, including superoxide dismutase 1, fused in liposarcoma, and TAR DNA-binding protein 43 (TDP-43), are substrates for sumoylation. Additionally, recent studies in cellular and animal models of ALS revealed that sumoylation of these proteins impact their localization, longevity, and how they functionally perform in disease, providing novel areas for mechanistic investigations and therapeutics. In this article, we summarize the current literature examining the impact of sumoylation of critical proteins involved in ALS and discuss the potential impact for the pathogenesis of the disease. In addition, we report and discuss the implications of new evidence demonstrating that sumoylation of a fragment derived from the proteolytic cleavage of the astroglial glutamate transporter, EAAT2, plays a direct role in downregulating the expression levels of full-length EAAT2 by binding to a regulatory region of its promoter.

Author(s): 
Foran, Emily
Rosenblum, Lauren
Bogush, Alexey I.
Trotti, Davide
Item Type: 
Journal Article
Publication Title: 
Neuromolecular Medicine
Journal Abbreviation: 
Neuromolecular Med.
Publication Date: 
2013-12
Publication Year: 
2013
Pages: 
760-770
Volume: 
15
Issue: 
4
ISSN: 
1559-1174
DOI: 
10.1007/s12017-013-8262-x
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 24062161 PMCID: PMC3832993

Turabian/Chicago Citation

Emily Foran, Lauren Rosenblum, Alexey I. Bogush and Davide Trotti. 2013-12. "Sumoylation of critical proteins in amyotrophic lateral sclerosis: emerging pathways of pathogenesis." Neuromolecular Medicine 15: 4: 760-770. 10.1007/s12017-013-8262-x.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1007/s12017-013-8262-x | issn = 1559-1174 | volume = 15 | pages = 760-770 | last = Foran | first = Emily | coauthors = Rosenblum, Lauren, Bogush, Alexey I., Trotti, Davide | title = Sumoylation of critical proteins in amyotrophic lateral sclerosis: emerging pathways of pathogenesis | journal = Neuromolecular Medicine | date = 2013-12 | pmid = | pmc = }} </ref>