Symptom management in pediatric oncology remains a problem. Despite remarkable pharmacologic and surgical advances, children continue to report symptoms as the most troublesome aspect of cancer treatment. However, there are additional therapies that are not considered standard symptom management, such as acupuncture and guided imagery. These nonpharmacologic adjunctive therapies are a potential source of assistance for children with unrelenting pain, nausea, or other unpleasant symptoms due to cancer treatment. This article summarizes research studies that have examined nonpharmacologic therapies for symptom management in pediatric oncology.