A urinary biomarker profile for children with HIV-associated renal diseases

Human immunodeficiency virus (HIV)-infected children are at risk of developing several types of renal diseases, including HIV-associated nephropathy (HIVAN), which is usually seen during late stages of infection in children with a high viral load. This disease is defined by the presence of proteinuria associated with mesangial hyperplasia and/or global-focal segmental glomerulosclerosis combined with microcystic transformation of the renal tubules. Because HIVAN can have an insidious clinical onset, renal biopsy is the only definitive way of establishing a diagnosis. Given the risk of performing this procedure in HIV-infected children with other AIDS-defining illness, we sought to identify informative biomarkers such as growth factors in the urine of 55 HIV-infected children that might be predictive of the extent and activity of the renal lesions characteristic of HIVAN. We found that the levels of epidermal growth factor were lower in the urine of children with renal disease, whereas levels of fibroblast growth factor-2 and metalloproteinase-2 were higher as compared with those levels in infected children without renal disease. Similar changes were observed in HIV-Tg26 mice correlating with the progression of renal disease in this model of HIVAN. Our findings suggest that this urinary growth factor profile may be useful in facilitating the diagnosis of HIV-infected children at risk of developing HIVAN when interpreted in the appropriate clinical setting.

Soler-García, Angel A.
Rakhmanina, Natella Y.
Mattison, Parnell C.
Ray, Patricio E.
Item Type: 
Journal Article
Publication Title: 
Kidney International
Journal Abbreviation: 
Kidney Int.
Publication Date: 
Jul 2009
Publication Year: 
Library Catalog: 
NCBI Published Medical (?)
PMID: 19357719 PMCID: PMC2778294

Turabian/Chicago Citation

Angel A. Soler-García, Natella Y. Rakhmanina, Parnell C. Mattison and Patricio E. Ray. Jul 2009. "A urinary biomarker profile for children with HIV-associated renal diseases." Kidney International 76: 2: 207-214. 10.1038/ki.2009.115.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1038/ki.2009.115 | issn = 1523-1755 | volume = 76 | pages = 207-214 | last = Soler-García | first = Angel A. | coauthors = Rakhmanina, Natella Y., Mattison, Parnell C., Ray, Patricio E. | title = A urinary biomarker profile for children with HIV-associated renal diseases | journal = Kidney International | date = Jul 2009 | pmid = | pmc = }} </ref>