academic

Publication Title: 
Schizophrenia Bulletin

Low birth weight (LBW) and hypoxia are among the environmental factors most reliably associated with schizophrenia; however, the nature of this relationship is unclear and both gene-environment interaction and gene-environment covariation models have been proposed as explanations. High-risk (HR) designs that explore whether obstetric complications differentially predict outcomes in offspring at low risk (LR) vs HR for schizophrenia, while accounting for differences in rates of maternal risk factors, may shed light on this question.

Author(s): 
Forsyth, Jennifer K.
Ellman, Lauren M.
Tanskanen, Antti
Mustonen, Ulla
Huttunen, Matti O.
Suvisaari, Jaana
Cannon, Tyrone D.
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