Alkenes

Publication Title: 
The FEBS journal

Lipocalins are a family of proteins characterized by a conserved eight-stranded ?-barrel structure with a ligand-binding pocket. They perform a wide range of biological functions and this functional multiplicity must relate to the lipid partner involved. Apolipoprotein D (ApoD) and its insect homologues, Lazarillo (Laz) and neural Lazarillo (NLaz), share common ancestral functions like longevity, stress resistance and lipid metabolism regulation, coexisting with very specialized functions, like courtship behavior.

Author(s): 
Ruiz, Mario
Sanchez, Diego
Correnti, Colin
Strong, Roland K.
Ganfornina, Maria D.
Publication Title: 
The Journal of Organic Chemistry

The Pd-catalyzed TBHP-mediated Wacker-type oxidation of internal alkenes is reported. The reaction uses 2-(4,5-dihydro-2-oxazolyl)quinoline (Quinox) as ligand and TBHP(aq) as oxidant to deliver single ketone constitutional isomer products in a predictable fashion from electronically biased olefins. This methodology is showcased through its application on an advanced intermediate in the total synthesis of the antimalarial drug artemisinin.

Author(s): 
DeLuca, Ryan J.
Edwards, Jennifer L.
Steffens, Laura D.
Michel, Brian W.
Qiao, Xiaoxiao
Zhu, Chunyin
Cook, Silas P.
Sigman, Matthew S.
Publication Title: 
Journal of Zhejiang University. Science. B

OBJECTIVE: Aroma is the core factor in aromatherapy. Sensory evaluation of aromas differed among three sweet osmanthus (Osmanthus fragrans) cultivar groups. The purpose of this study was to investigate the aroma-active compounds responsible for these differences. METHODS: Gas chromatography-olfactometry (GC-O) and GC-mass spectrometry (GC-MS) were used to analyze the aroma-active compounds and volatiles of creamy-white ('Houban Yingui', HBYG), yellow ('Liuye Jingui', LYJG), and orange ('Gecheng Dangui', GCDG) cultivars.

Author(s): 
Cai, Xuan
Mai, Rong-zhang
Zou, Jing-jing
Zhang, Hong-Yan
Zeng, Xiang-ling
Zheng, Ri-ru
Wang, Cai-yun
Publication Title: 
The Journal of Toxicological Sciences

Chemical characterization and acute and sub-acute toxicity study of Trikatu, a generic herbal formulation of Indian system of medicine, was carried out in Charles Foster (CF) rats for safety profiling.

Author(s): 
Chanda, Debabrata
Shanker, Karuna
Pal, Anirban
Luqman, Suaib
Bawankule, Dnyaneshwar Umrao
Mani, Dayanandan
Darokar, Mahendra Pandurang
Publication Title: 
The Journal of Toxicological Sciences

Chemical characterization and acute and sub-acute toxicity study of Trikatu, a generic herbal formulation of Indian system of medicine, was carried out in Charles Foster (CF) rats for safety profiling.

Author(s): 
Chanda, Debabrata
Shanker, Karuna
Pal, Anirban
Luqman, Suaib
Bawankule, Dnyaneshwar Umrao
Mani, Dayanandan
Darokar, Mahendra Pandurang
Publication Title: 
Journal of Ethnopharmacology

ETHNOPHARMACOLOGICAL RELEVANCE: The fruits of Semecarpus anacardium L. f. (Anacardiaceae) are used in Ayurvedic medicine and also in Iranian Traditional Medicine for various indications, among those for retarding and treatment of dementia. AIM OF THE STUDY: The severity of Alzheimer's disease obviously correlates with a cholinergic deficit. In a screening for acetylcholinesterase (AChE) inhibitory activity, an extract from the fruit resin of Semecarpus anacardium was among the most active ones.

Author(s): 
Adhami, H. R.
Linder, T.
Kaehlig, H.
Schuster, D.
Zehl, M.
Krenn, L.
Publication Title: 
PloS One

Extra virgin olive oil (EVOO) and olives, key sources of unsaturated fatty acids in the Mediterranean diet, provide health benefits to humans. Nitric oxide (•NO) and nitrite (NO2 (-))-dependent reactions of unsaturated fatty acids yield electrophilic nitroalkene derivatives (NO2-FA) that manifest salutary pleiotropic cell signaling responses in mammals. Herein, the endogenous presence of NO2-FA in both EVOO and fresh olives was demonstrated by mass spectrometry.

Author(s): 
Fazzari, Marco
Trostchansky, Andrés
Schopfer, Francisco J.
Salvatore, Sonia R.
Sánchez-Calvo, Beatriz
Vitturi, Dario
Valderrama, Raquel
Barroso, Juan B.
Radi, Rafael
Freeman, Bruce A.
Rubbo, Homero
Publication Title: 
Journal of Immunotoxicology

Perfluoroalkyl substances (PFAS) are suggested to have immunosuppressive effects; exposure in utero and in the first years of life is of special concern as fetuses and small children are highly vulnerable to toxicant exposure. The objective of this study was to investigate the effect of pre-natal exposure to PFAS on responses to pediatric vaccines and immune-related health outcomes in children up to 3 years of age.

Author(s): 
Granum, Berit
Haug, Line S.
Namork, Ellen
Stølevik, Solvor B.
Thomsen, Cathrine
Aaberge, Ingeborg S.
van Loveren, Henk
Løvik, Martinus
Nygaard, Unni C.
Publication Title: 
Scientific Reports

FAAH-like anandamide transporter (FLAT) regulates anandamide transport for hydrolysis and may be an attractive drug target for pain regulation. We aimed to discover potential FLAT antagonists from traditional Chinese medicine (TCM) using virtual screening, ligand-based drug design and molecular dynamics simulation (MD). Guineensine and Retrofractamide A exhibited high Dock Scores in FLAT.

Author(s): 
Tou, Weng Ieong
Chang, Su-Sen
Lee, Cheng-Chun
Chen, Calvin Yu-Chian
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