Alzheimer Disease

Publication Title: 
International Journal of Clinical Practice

BACKGROUND: Acupuncture is often used as a treatment for dementia and is claimed to be effective in improving intelligence. AIMS: The objective of this review is to assess the clinical evidence for or against acupuncture as a treatment for Alzheimer's disease (AD). METHODS: We searched the literature using 17 databases from their inception to August 2008, without language restrictions. We included all randomised clinical trials (RCTs) of needle acupuncture to treat human patients suffering from AD. Methodological quality was assessed using the Jadad score.

Author(s): 
Lee, M. S.
Shin, B.-C.
Ernst, E.
Publication Title: 
International Journal of Clinical Practice

BACKGROUND: Acupuncture is often used as a treatment for dementia and is claimed to be effective in improving intelligence. AIMS: The objective of this review is to assess the clinical evidence for or against acupuncture as a treatment for Alzheimer's disease (AD). METHODS: We searched the literature using 17 databases from their inception to August 2008, without language restrictions. We included all randomised clinical trials (RCTs) of needle acupuncture to treat human patients suffering from AD. Methodological quality was assessed using the Jadad score.

Author(s): 
Lee, M. S.
Shin, B.-C.
Ernst, E.
Publication Title: 
BMJ open

INTRODUCTION: The aim of this protocol is to provide the methods used to assess the effectiveness and safety of acupuncture for the treatment of patients with Alzheimer's disease. METHODS AND ANALYSIS: We will search the following electronic databases: The Cochrane Library, PubMed, Medline, Embase, PsycINFO, Chinese Biomedical Literature Database, Chinese Medical Current Contents and China National Knowledge Infrastructure without restriction of language and publication status.

Author(s): 
Zhou, Jing
Peng, Weina
Li, Wang
Liu, Zhishun
Publication Title: 
Medicine

The use of acupuncture for treating Alzheimer disease (AD) has been increasing in frequency over recent years. As more studies are conducted on the use of acupuncture for treating AD, it is necessary to re-assess the effectiveness and safety of this practice. The objective of this study was to assess the effectiveness and safety of acupuncture for treating AD.

Author(s): 
Zhou, Jing
Peng, Weina
Xu, Min
Li, Wang
Liu, Zhishun
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Egyptians recognized the healing power of herbs and used them in their medicinal formulations. Nowadays, "Attarin" drug shops and the public use mainly the Unani medicinal system for treatment of their health problems including improvement of memory and old age related diseases. Numerous medicinal plants have been described in old literature of Arabic traditional medicine for treatment of Alzheimer's disease (AD) (or to strengthen memory).

Author(s): 
Ali, Shereen K.
Hamed, Ahmed R.
Soltan, Maha M.
Hegazy, Usama M.
Elgorashi, Esameldin E.
El-Garf, Ibrahim A.
Hussein, Ahmed A.
Publication Title: 
IUBMB life

In Roman mythology, Janus was the god of gates, doors, beginnings and endings. He was usually depicted with two faces looking in opposite directions. Janus was frequently used to symbolize change and transitions, such as the progression from past to future or from one viewpoint to another. 2,4-dinitrophenol (DNP) and other nitrophenols have long been known to be toxic at high concentrations (the 'bad' face of DNP), an effect that appears essentially related to interference with cellular energy metabolism due to uncoupling of mitochondrial oxidative phosphorylation.

Author(s): 
De Felice, Fernanda G.
Ferreira, SÈrgio T.
Publication Title: 
Journal of Neurology

BACKGROUND: Memantine, an N-methyl-D-aspartate (NMDA) receptor antagonist, has been shown to be safe and to have beneficial effects on cognition, function, behavior, and global patient status in patients with Alzheimer's disease (AD) in studies lasting 3-6 months. It is approved in the U.S. and Europe for the treatment of moderate to severe AD and is currently under investigation for mild to moderate AD. OBJECTIVE: To evaluate the long-term safety of memantine in patients with mild to moderate AD and to investigate the tolerability of once-daily dose administration.

Author(s): 
Ott, Brian R.
Blake, Lesley M.
Kagan, Ethel
Resnick, Malca
Memantine MEM-MD-11AB Study Group
Publication Title: 
The American Journal of Geriatric Psychiatry: Official Journal of the American Association for Geriatric Psychiatry

OBJECTIVE: A systematic genome survey was initiated to identify loci that affect the likelihood of reaching age 90 with preserved cognition. This communication describes the clinical characterization and comparison of the experimental groups, validation of the experimental method, and results for the Y chromosome. METHODS: The genome survey was conducted at 10 cM resolution for simple sequence tandem repeat polymorphisms (SSTRPs) that identify genes for successful aging by virtue of linkage disequilibrium.

Author(s): 
Zubenko, George S.
Stiffler, J. Scott
Hughes, Hugh B.
Fatigati, Mario J.
Zubenko, Wendy N.
Publication Title: 
Neurology

OBJECTIVE: To examine the relative risk and population attributable risk (PAR) of death with dementia of varying type and severity and other risk factors in a population of exceptional longevity. METHODS: Deaths were monitored over 5 years using vital statistics records and newspaper obituaries in 355 individuals with prevalent dementia and 4,328 without in Cache County, UT. Mean age was 83.3 (SD 7.0) years with dementia and 73.7 (SD 6.8) years without. History of coronary artery disease, hypertension, diabetes, and other life-shortening illness was ascertained from interviews.

Author(s): 
Tschanz, J. T.
Corcoran, C.
Skoog, I.
Khachaturian, A. S.
Herrick, J.
Hayden, K. M.
Welsh-Bohmer, K. A.
Calvert, T.
Norton, M. C.
Zandi, P.
Breitner, J. C. S.
Cache County Study Group
Publication Title: 
JAMA: the journal of the American Medical Association

CONTEXT: Polymorphisms in the cholesteryl ester transfer protein (CETP) gene have been associated with exceptional longevity and lower cardiovascular risk, but associations with memory decline and dementia risk are unclear. OBJECTIVE: To test the hypothesis that a single-nucleotide polymorphism (SNP) at CETP codon 405 (isoleucine to valine V405; SNP rs5882) is associated with a lower rate of memory decline and lower risk of incident dementia, including Alzheimer disease (AD).

Author(s): 
Sanders, Amy E.
Wang, Cuiling
Katz, Mindy
Derby, Carol A.
Barzilai, Nir
Ozelius, Laurie
Lipton, Richard B.

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