antipsychotics

Publication Title: 
Expert Opinion on Drug Discovery

INTRODUCTION: Schizophrenia is a major psychiatric disorder that afflicts about 1% of the world's population, falling into the top 10 medical disorders causing disability. Existing therapeutic strategies have had limited success; they have poor effects on core cognitive impairment and long-term disability. They are also burdened by relevant side effects. Although new antipsychotic medications have been launched in the past decades, there has been a general lack of significant innovation over the past 60 years.

Author(s): 
Bosia, Marta
Pigoni, Alessandro
Cavallaro, Roberto
Publication Title: 
Epigenomics

Evidence for involvement of DNA methylation in psychosis forms the focus of this perspective. Of interest are results from two independent sets of experiments including rats treated with antipsychotic drugs and monozygotic twins discordant for schizophrenia. The results show that DNA methylation is increased in rats treated with antipsychotic drugs, reflecting the global effect of the drugs. Some of these changes are also seen in affected schizophrenic twins that were treated with antipsychotics.

Author(s): 
Castellani, Christina A.
Melka, Melkaye G.
Diehl, Eric J.
Laufer, Benjamin I.
O'Reilly, Richard L.
Singh, Shiva M.
Publication Title: 
ACS chemical neuroscience

Histone modifications and DNA methylation represent central dynamic and reversible processes that regulate gene expression and contribute to cellular phenotypes. These epigenetic marks have been shown to play fundamental roles in a diverse set of signaling and behavioral outcomes. Serotonin is a monoamine that regulates numerous physiological responses including those in the central nervous system.

Author(s): 
Holloway, Terrell
Gonz·lez-Maeso, Javier
Publication Title: 
Cellular Signalling

Histone modifications and DNA methylation represent central dynamic and reversible processes that regulate gene expression and contribute to cellular phenotypes. These epigenetic marks have been shown to play fundamental roles in a diverse set of signaling and behavioral outcomes.

Author(s): 
Ibi, Daisuke
Gonz·lez-Maeso, Javier
Publication Title: 
Epigenomics

AIM: In view of the potential effects of psychiatric drugs on DNA methylation, we investigated whether medication use in bipolar disorder is associated with DNA methylation signatures. EXPERIMENTAL PROCEDURES: Blood-based DNA methylation patterns of six frequently used psychotropic drugs (lithium, quetiapine, olanzapine, lamotrigine, carbamazepine, and valproic acid) were examined in 172 bipolar disorder patients. After adjustment for cell type composition, we investigated gene networks, principal components, hypothesis-driven genes and epigenome-wide individual loci.

Author(s): 
Houtepen, Lotte C.
van Bergen, Annet H.
Vinkers, Christiaan H.
Boks, Marco P. M.
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