Antirheumatic Agents

Publication Title: 
International Journal of Rheumatic Diseases

AIM: To identify the psychological interventions for which there is consistent, high quality evidence of efficacy in the treatment of patients with rheumatoid arthritis (RA). METHOD: A computer-aided search and manual screening of identified papers was conducted. Randomised controlled trials published in English in peer-reviewed journals, assessing the use of psychological interventions in adult patients with RA were included. RESULTS: Thirty-four papers published between 1981 and 2009 encompassing 31 studies with 2021 patients were included.

Author(s): 
Dissanayake, Rukmal Kumari
Bertouch, James V.
Publication Title: 
Clinical Therapeutics

BACKGROUND: Clinically relevant drug-drug interactions (DDIs) must be recognized in a timely manner and managed appropriately to prevent adverse drug reactions or therapeutic failure. Because the evidence for most DDIs is based on case reports or poorly documented clinical information, there is a need for better assessment of their clinical relevance.

Author(s): 
van Roon, Eric N.
van den Bemt, Patricia M. L. A.
Jansen, Tim L. Th A.
Houtman, Nella M.
van de Laar, Mart A. F. J.
Brouwers, Jacobus R. B. J.
Publication Title: 
Forschende Komplementarmedizin (2006)

BACKGROUND: We conducted a meta-analysis evaluating the efficacy and safety of acupuncture compared to disease-modifying antirheumatic drugs in patients with ankylosing spondylitis. METHODS: Four databases including Pubmed, EMBASE, Cochrane library, and ISI Web of Science were searched in December 2014, taking also the reference section into account. Randomized controlled trials that aimed to assess the efficacy of acupuncture therapy were identified.

Author(s): 
Lv, Zheng-tao
Zhou, Xiang
Chen, An-Min
Publication Title: 
Seminars in Arthritis and Rheumatism

OBJECTIVE: To systematically review all randomized controlled trials (RCTs) on the effectiveness of Ayurvedic medicine for rheumatoid arthritis (RA). METHODS: Computerized literature searches for all RCTs of Ayurvedic medicine for RA in the following databases: Medline (March 1969 to March 2003), Embase (February 1985 to February 2003), AMED (March 1980 to March 2003), Cochrane Controlled Trial Register (October 1997 to March 2003), and the abstract service of Central Council for Research in Ayurveda and Siddha (CCRAS; 1976 to March 2003).

Author(s): 
Park, Jongbae
Ernst, Edzard
Publication Title: 
The Journal of Pharmacy and Pharmacology

OBJECTIVE: This study evaluates the anti-arthritic effect of Terminalia chebula hydroalcoholic extract (TCHE) in experimental models and attempts to correlate the effect of treatment on macrophage-derived pro-inflammatory cytokine expression and extent of disease activity. METHODS: Arthritis was induced in rats by subplantar administration of either formaldehyde or complete Freund's adjuvant (CFA). Joint size was measured at regular intervals by using a micrometer screw gauge.

Author(s): 
Nair, Vinod
Singh, Surender
Gupta, Yogendra Kumar
Publication Title: 
Health Services Research

OBJECTIVES: To examine the impact of benefit generosity and household health care financial burden on the demand for specialty drugs in the treatment of rheumatoid arthritis (RA). DATA SOURCES/STUDY SETTING: Enrollment, claims, and benefit design information for 35 large private employers during 2000-2005. STUDY DESIGN: We estimated multivariate models of the effects of benefit generosity and household financial burden on initiation and continuation of biologic therapies.

Author(s): 
Karaca-Mandic, Pinar
Joyce, Geoffrey F.
Goldman, Dana P.
Laouri, Marianne
Publication Title: 
Journal of Managed Care & Specialty Pharmacy

BACKGROUND: Introduction of biologic disease-modifying antirheumatic drugs (DMARDs) has revolutionized treatment in patients with rheumatoid arthritis (RA). However, due to substantially higher costs of biologics compared with nonbiologics, patients with less insurance generosity may have difficulty affording these agents, which may lead to potential access disparities. OBJECTIVE: To identify factors affecting treatment initiation with tumor necrosis factor (TNF)-? inhibitor biologics in patients with RA.

Author(s): 
Desai, Rishi J.
Rao, Jaya K.
Hansen, Richard A.
Fang, Gang
Maciejewski, Matthew L.
Farley, Joel F.
Publication Title: 
Arthritis and Rheumatism

OBJECTIVE: To evaluate the informed consent process for a clinical trial of intravenous doxycycline for rheumatoid arthritis. METHODS: Participants completed a self-administered questionnaire about the consent process at baseline and 16 weeks following enrollment in a clinical trial. RESULTS: Respondents (n = 30) affirmed voluntary participation in the parent trial. Participants acknowledged hope and altruism as reasons for entering the trial more than expectation of personal benefit or outside influences.

Author(s): 
Criscione, Lisa G.
Sugarman, Jeremy
Sanders, Linda
Pisetsky, David S.
St Clair, E. William
Publication Title: 
The European journal of health economics: HEPAC: health economics in prevention and care

To curb the heavily increasing drug budgets some Danish counties have introduced voluntary agreements between general practitioners (GPs) and health authorities. We extend the models of generic prescription by Hellerstein (Rand J Econ 29(1):108-136, 1998) and Lundin (J Health Econ 19:639-662, 2000) to allow for substitution between analogues and use difference-in-difference models to assess the effect on two drug groups (lipid-lowering and rheumatism drugs). For both drug groups we find evidence of a significant effect of the intervention.

Author(s): 
Olsen, Kim Rose
Gyrd-Hansen, Dorte
Boegh, Andreas
Hansen, Sofie Hartung
Publication Title: 
Bulletin of the NYU hospital for joint diseases

There are certain thought barriers involved in making diagnostic-classification criteria in diseases of unknown origin. Among these are a lack of appreciation of the issue of circular logic, the basic oneness of diagnostic and classification criteria, the lack of appreciation as to why we make such criteria in the first place, and the lack of importance informing our patients that we do as well as should treat them without a frm diagnosis in many instances.

Author(s): 
Yazici, Hasan

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