ARNTL Transcription Factors

Publication Title: 
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Kahn, Arnold J.
Publication Title: 
Journal of Pineal Research

Prostate cancer (PCa) is a major age-related malignancy as increasing age correlates with increased risk for developing this neoplasm. Similarly, alterations in circadian rhythms have also been associated with the aging population and cancer risk. The pineal hormone melatonin is known to regulate circadian rhythms, which is under the control of a core set of genes: Period 1, 2, 3 (Per 1-3); Cryptochrome 1, 2 (Cry 1, 2); Clock, and Bmal 1, 2.

Jung-Hynes, Brittney
Huang, Wei
Reiter, Russel J.
Ahmad, Nihal
Publication Title: 
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology

To determine the effects of age and lipoic acid supplementation on hepatic gene expression, we fed young (3 mo) and old (24 mo) male Fischer 344 rats a diet with or without 0.2% (wt/wt) R-α-lipoic acid (LA) for 2 wk. Total RNA isolated from liver tissue was analyzed by Affymetrix microarray to examine changes in transcriptional profiles. Results showed elevated proinflammatory gene expression in the aging liver and evidence for increased immune cell activation and tissue remodeling, together representing 45% of the age-related transcriptome changes.

Finlay, Liam A.
Michels, Alex J.
Butler, Judy A.
Smith, Eric J.
Monette, Jeffrey S.
Moreau, Régis F.
Petersen, Shay Kate
Frei, Balz
Hagen, Tory M.
Publication Title: 
American Journal of Physiology. Endocrinology and Metabolism

Robust biological rhythms have been shown to affect life span. Biological clocks can be entrained by two feeding regimens, restricted feeding (RF) and caloric restriction (CR). RF restricts the time of food availability, whereas CR restricts the amount of calories with temporal food consumption. CR is known to retard aging and extend life span of animals via yet-unknown pathways. We hypothesize that resetting the biological clock could be one possible mechanism by which CR extends life span.

Froy, Oren
Chapnik, Nava
Miskin, Ruth
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