Ascorbic Acid

Publication Title: 
Alternative Therapies in Health and Medicine

PURPOSE: The purpose of this study was to test the effectiveness of an integrative medicine approach to the management of asthma compared to standard clinical care on quality of life (QOL) and clinical outcomes. METHODS: This was a prospective parallel group repeated measurement randomized design. Participants were adults aged 18 to 80 years with asthma. The intervention consisted of six group sessions on the use of nutritional manipulation, yoga techniques, and journaling. Participants also received nutritional supplements: fish oil, vitamin C, and a standardized hops extract.

Kligler, Benjamin
Homel, Peter
Blank, Arthur E.
Kenney, Jeanne
Levenson, Hanniel
Merrell, Woodson
Publication Title: 
BMJ (Clinical research ed.)

Reviewing the literature is a scientific inquiry that needs a clear design to preclude bias. It is a real enterprise if one aims at completeness of the literature on a certain subject. Going through refereed English language journals is not enough. On line databases are helpful, but mainly as a starting point. This article gives examples of systematic reviews on vitamin C and the common cold, pyridoxine against the premenstrual syndrome, homeopathy, and physiotherapy.

Knipschild, P.
Publication Title: 

Four aqueous extracts from different parts of medicinal plants used in Ayurveda (an ancient Indian Medicine) viz., Momardica charantia Linn (AP1), Glycyrrhiza glabra (AP2), Acacia catechu (AP3), and Terminalia chebula (AP4) were examined for their potential as antioxidants. The antioxidant activity of these extracts was tested by studying the inhibition of radiation induced lipid peroxidation in rat liver microsomes at different doses in the range of 100-600 Gy as estimated by thiobarbituric acid reactive substances (TBARS).

Naik, G. H.
Priyadarsini, K. I.
Satav, J. G.
Banavalikar, M. M.
Sohoni, D. P.
Biyani, M. K.
Mohan, H.
Publication Title: 
Human & Experimental Toxicology

HP-1 a herbal formulation comprising of Phyllanthus niruri and extracts of Terminalia belerica, Terminalia chebula, Phyllanthus emblica and Tinospora cordifolia has been evaluated for hepatoprotective activity against carbon tetrachloride (CCl4) induced toxicity. Results show that HP-1 reversed the leakage of lactate dehydrogenase (LDH) and glutamate pyruvate transaminase (GPT) and prevented the depletion of glutathione (GSH) levels in a primary monolayer culture of rat hepatocytes (in vitro).

Tasaduq, S. A.
Singh, K.
Sethi, S.
Sharma, S. C.
Bedi, K. L.
Singh, J.
Jaggi, B. S.
Johri, R. K.
Publication Title: 
Indian Journal of Biochemistry & Biophysics

Antioxidant activity of ethanolic extract of fruits of Terminalia chebula (500 mg/kg body wt, orally for 30 days) against isoproterenol-induced oxidative stress was investigated in rats. The levels of serum lipid peroxides, iron, ascorbic acid, vitamin E, plasma iron-binding capacity, and the activities of ceruloplasmin and glutathione were assayed, in addition to the activities of the antioxidant enzymes--glutathione peroxidase, glutathione reductase, glutathione-S-transferase, superoxide dismutase and catalase in the heart tissue.

Suchalatha, Subramaniyan
Srinivasulu, Chennam
Devi, Shyamala
Publication Title: 
Molecular and Cellular Biochemistry

Stress is one of the basic factors in the etiology of number of diseases. The present study was aimed to investigate the effect of Triphala (Terminalia chebula, Terminalia belerica and Emblica officinalis) on noise-stress induced alterations in the antioxidant status and on the cell-mediated immune response in Wistar strain male albino rats. Noise-stress employed in this study was 100 dB for 4 h/d/15 days and Triphala was used at a dose of 1 g/kg/b.w/48 days.

Srikumar, Ramasundaram
Parthasarathy, Narayanaperumal Jeya
Manikandan, Sundaramagalingam
Narayanan, Govindarajulu Sathya
Sheeladevi, Rathinasamy
Publication Title: 
Cell Biochemistry and Function

We evaluated the preventive effects of Terminalia chebula (T. chebula) aqueous extract on oxidative and antioxidative status in liver and kidney of aged rats compared to young albino rats. The concentrations of malondialdehyde (MDA), lipofuscin (LF), protein carbonyls (PCO), activities of xantione oxidase (XO), manganese-superoxide dismutase (MnSOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione-S-transferase (GST), and glucose-6-phosphate dehydrogenase (G6PDH), levels of glutathione (GSH), vitamin C and vitamin E were used as biomarkers.

Mahesh, Ramalingam
Bhuvana, Shanmugham
Begum, Vava Mohaideen Hazeena
Publication Title: 
International Journal of Food Sciences and Nutrition

Fifteen fruits commonly used by the ethnic population in Nepal were studied for the antioxidant activity and total polyphenol content (TPC). Among them, Terminalia bellirica, Terminalia chebula, Phyllanthus emblica and Spondias pinnata were the most potent antioxidants as compared with vitamin C based on the 1,1-diphenyl-2-picryl hydrazyl radical assay. These fruits also contained high TPCs. Spondias pinnata, Pyrularia edulis, Melastoma malabathricum, Cipadema bacifera and Choerospondias axillaries fruits were evaluated for the first time.

Chalise, Jaya Prakash
Acharya, Kalpana
Gurung, Nirmala
Bhusal, Ram Prasad
Gurung, Reenu
Skalko-Basnet, Natasa
Basnet, Purusotam
Publication Title: 
Food Chemistry

Wild edible fruits contribute significantly to the nutritional security of mankind across the globe. However, detailed analyses of health promoting bioactive compounds and antioxidants are lacking, especially in Himalayan wild edible fruits.

Bhatt, Indra D.
Rawat, Sandeep
Badhani, Amit
Rawal, Ranbeer S.
Publication Title: 
Biochemical and Biophysical Research Communications

Cellular senescence is a tumor suppression mechanism. We previously reported that CKII downregulation induces senescence in human lung fibroblast IMR-90 and colon cancer HCT116 cells. In this study, potential longevity drugs, including rapamycin, vitamin C, and vitamin E, blocked CKII downregulation-mediated senescence through reduction of reactive oxygen species (ROS) production in HCT116 cells.

Park, Ji Hye
Kim, Jin Joo
Bae, Young-Seuk


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