Blood Cells

Publication Title: 
Complementary Therapies in Medicine

OBJECTIVE: Systematic assessment of the in vitro research on high potency effects. METHOD: Publications of experiments were collected through databases, experts, previous reviews, citation tracking. INCLUSION CRITERIA: stepwise agitated dilutions <10(-23); cells or molecules from human or animal. Experiments were assessed with the modified SAPEH score. RESULTS: From 75 publications, 67 experiments (1/3 of them replications) were evaluated. Nearly 3/4 of them found a high potency effect, and 2/3 of those 18 that scored 6 points or more and controlled contamination.

Author(s): 
Witt, Claudia M.
Bluth, Michael
Albrecht, Henning
Weisshuhn, Thorolf E. R.
Baumgartner, Stephan
Willich, Stefan N.
Publication Title: 
Aging Cell

Aging poses one of the largest risk factors for the development of cardiovascular disease. The increased propensity toward vascular pathology with advancing age maybe explained, in part, by a reduction in the ability of circulating endothelial progenitor cells to contribute to vascular repair and regeneration. Although there is evidence to suggest that colony forming unit-Hill cells and circulating angiogenic cells are subject to age-associated changes that impair their function, the impact of aging on human outgrowth endothelial cell (OEC) function has been less studied.

Author(s): 
Williamson, Kate A.
Hamilton, Andrew
Reynolds, John A.
Sipos, Peter
Crocker, Ian
Stringer, Sally E.
Alexander, Yvonne M.
Publication Title: 
The International Journal of Neuroscience

ABSTRACT DNA methylation, which has been investigated extensively recently, has been studied in various human diseases, including cancer, and the analysis of DNA methylation has provided useful biomarkers for diagnosing cancer, monitoring treatment, and predicting the prognosis of cancer. Recently, aberrant DNA methylation has been reported in various neuropsychiatric diseases in both postmortem brains and peripheral blood cells.

Author(s): 
Ai, Sanxi
Shen, Lu
Guo, Jifeng
Feng, Xiang
Tang, Beisha
Publication Title: 
Biological Psychiatry

Peripheral samples, such as blood and skin, have been used for decades in psychiatric research as surrogates for central nervous system samples. Although the validity of the data obtained from peripheral samples has been questioned and other state-of-the-art techniques, such as human brain imaging, genomics, and induced pluripotent stem cells, seem to reduce the value of peripheral cells, accumulating evidence has suggested that revisiting peripheral samples is worthwhile.

Author(s): 
Hayashi-Takagi, Akiko
Vawter, Marquis P.
Iwamoto, Kazuya
Publication Title: 
The American Journal of Tropical Medicine and Hygiene

The present study reports the tissue distribution, pharmacokinetics, mass balance, and elimination of [(14)C] artesunate (AS) following single intravenous administration in rats. Protein binding was performed with rat and human plasma. Radioactivity and drug levels in blood, plasma, tissues, urine, and feces up to 192 hours were collected and measured. The mean terminal half-life of plasma (76 h) and blood (105 h) radioactivity was prolonged compared with that of unchanged AS (0.43 h) and dihydroartemisinin (0.75 h), an active metabolite of AS.

Author(s): 
Li, Qigui
Xie, Lisa H.
Haeberle, Adam
Zhang, Jing
Weina, Peter
Publication Title: 
Malaria Journal

BACKGROUND: Artesunate-amodiaquine (AS&AQ) is a widely used artemisinin combination therapy (ACT) for falciparum malaria. A comprehensive appreciation of its effects on haematology vs other anti-malarials is needed in view of potential safety liabilities. METHODS: Individual-patient data analysis conducted on a database from seven randomized controlled trials conducted in sub-Saharan African comparing AS&AQ to reference treatments in uncomplicated falciparum malaria patients of all ages.

Author(s): 
Zwang, Julien
Ndiaye, Jean-Louis
Djimde, Abdoulaye
Dorsey, Grant
Mårtensson, Andreas
Karema, Corine
Olliaro, Piero
Publication Title: 
Journal of Ethnopharmacology

Caesalpinia bonducella FLEMING (Caesalpiniaceae) is a plant well known for its medicinal value in Indian Ayurveda. However, to prove its efficiency for the clinical utilization, more experimental data will be beneficial. AIMS OF THE STUDY: The present study involved the investigation of immunomodulatory activities of ethanolic extract of Caesalpinia bonducella seeds.

Author(s): 
Shukla, Shruti
Mehta, Archana
John, Jinu
Mehta, Pradeep
Vyas, Suresh Prasad
Shukla, Savita
Publication Title: 
Food & Function

Bacopa monnieri (L., BM) is a traditional Ayurvedic medicinal herb recognised for its efficacy in relieving acute pain and inflammation, as related to selective inhibition of cyclo-oxygenase-2 (COX-2) enzyme and consequent reduction in COX-2-mediated prostanoid mediators. BM is also associated with cognitive enhancing (nootropic) activity including improving memory free recall, observed after prolonged intake (>3 months).

Author(s): 
Williams, Roderick
Münch, Gerald
Gyengesi, Erika
Bennett, Louise
Publication Title: 
The Journal of Biological Chemistry

Neuroinflammation and traumatic brain injury involve activation of inflammatory cells and production of local pro-inflammatory mediators that can amplify tissue damage. Using LC-UV-MS-MS-based lipidomics in tandem with functional screening at the single-cell level in microfluidic chambers, we identified a series of novel bioactive oxygenated docosahexaenoyl ethanolamide- (DHEA) derived products that regulated leukocyte motility.

Author(s): 
Yang, Rong
Fredman, Gabrielle
Krishnamoorthy, Sriram
Agrawal, Nitin
Irimia, Daniel
Piomelli, Daniele
Serhan, Charles N.
Publication Title: 
Journal of Zhejiang University. Science. B

Psidium guajava (guava) leaf is a phytotherapic used in folk medicine to treat gastrointestinal and respiratory disturbances and is used as anti-inflammatory medicine. In nuclear medicine, blood constituents (BC) are labelled with technetium-99m ((99m)Tc) and used to image procedures. However, data have demonstrated that synthetic or natural drugs could modify the labelling of BC with (99m)Tc. The aim of this work was to evaluate the effects of aqueous extract of guava leaves on the labelling of BC with (99m)Tc.

Author(s): 
Abreu, P. R. C.
Almeida, M. C.
Bernardo, R. M.
Bernardo, L. C.
Brito, L. C.
Garcia, E. a. C.
Fonseca, A. S.
Bernardo-Filho, M.

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