Publication Title: 
Journal of Alternative and Complementary Medicine (New York, N.Y.)

OBJECTIVE: One aim of this study was to investigate the effects of acupuncture on cerebral function of patients with acute cerebral infarction. Another goal was to evaluate the relationship between acupuncture treatment and motor recovery patients with stroke and to provide a foundation for using acupuncture therapy for such patients. DESIGN: Twenty (20) patients with recent cerebral infarction were divided randomly to an acupuncture group and a control group. The infarction area in each patient was in the basal ganglia or included the basal ganglia with an area size of > 1 cm(2).

Shen, Yunxia
Li, Ming
Wei, Ruipeng
Lou, Mingwu
Publication Title: 
Forschende Komplementärmedizin (2006)

As a complementary medical procedure, acupuncture has a significant impact on the treatment of acute and chronic pain. Though the physiological mechanisms behind this method are still unclear, acupuncture has been claimed to rely also on changes in the central nervous system. Recent functional imaging studies indicate that the so-called default mode network (DMN) which consists of cortical midline structures and lateral parietal regions plays an important role in these processes. This brief overview describes the effects of analgesic acupuncture on the DMN architecture.

Otti, Alexander
Noll-Hussong, Michael
Publication Title: 
PloS One

BACKGROUND: In acupuncture brain imaging trials, there are many non-acupuncture factors confounding the neuronal mapping. The modality of the placebo, subjects' psychological attitude to acupuncture and their physical state are the three most confounding factors. OBJECTIVE: To obtain more precise and accurate cerebral fMRI mapping of acupuncture. DESIGN AND SETTING: A 2×2 randomized, controlled, participant-blinded cross-over factorial acupuncture trial was conducted at Xuanwu Hospital in Beijing, China.

Liu, Hua
Xu, Jianyang
Shan, Baoci
Li, Yongzhong
Li, Lin
Xue, Jingquan
Nie, Binbin
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: This study was designed to determine if electroacupuncture (EA) preconditioning improves tissue outcome and functional outcome following experimentally induced cerebral ischemia in mice. In addition, we investigated whether the expression of brain-derived neurotrophic factor (BDNF) and stromal cell derived factor-1α (SDF-1α) and infarct volume were related with improvement in neurological and motor function by interventions in this study.

Kim, Ji Hyun
Choi, Kyung Ha
Jang, Young Jung
Kim, Ha Neui
Bae, Sun Sik
Choi, Byung Tae
Shin, Hwa Kyoung
Publication Title: 
Journal of Neuroinflammation

BACKGROUND: Emerging studies have demonstrated that pretreatment with electroacupuncture (EA) induces significant tolerance to focal cerebral ischemia. The present study seeks to determine the involvement of monocyte chemotactic protein-induced protein 1 (MCPIP1), a recently identified novel modulator of inflammatory reactions, in the cerebral neuroprotection conferred by EA pretreatment in the animal model of focal cerebral ischemia and to elucidate the mechanisms of EA pretreatment-induced ischemic brain tolerance.

Jin, Zhuqing
Liang, Jian
Wang, Jing
Kolattukudy, Pappachan E.
Publication Title: 
PloS One

Acupuncture, an externally somatosensory stimulation in the Traditional Chinese Medicine, has been proposed about its modulations on the brain's default mode network (DMN). However, it is still unknown on how the internal brain resting networks are modulated and what inferences can be made about the physiological processes underlying these changes.

You, Youbo
Bai, Lijun
Dai, Ruwei
Cheng, Hao
Liu, Zhenyu
Wei, Wenjuan
Tian, Jie
Publication Title: 
Journal of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan / Sponsored by All-China Association of Traditional Chinese Medicine, Academy of Traditional Chinese Medicine

OBJECTIVES: Functional magnetic resonance imaging (fMRI) technology was used to study changes to the resting state blood flow in the brains of patients with knee osteoarthritis (KOA) before and after treatment with moxibustion at the acupoint of the left Dubi (ST 35) and to probe the cerebral mechanism underlying the effect of moxibustion. METHODS: The resting state brain function of 30 patients with left KOA was scanned with fMRI before and after treatment with moxibustion.

Xie, Hongwu
Xu, Fangming
Chen, Rixin
Luo, Tianyou
Chen, Mingren
Fang, Weidong
Lü, Fajin
Wu, Fei
Song, Yune
Xiong, Jun
Publication Title: 
Chinese Medical Journal

BACKGROUND: Previous studies have demonstrated that acupuncture could modulate various brain systems in the resting brain networks. Graph theoretical analysis offers a novel way to investigate the functional organization of the large-scale cortical networks modulated by acupuncture at whole brain level. In this study, we used wavelets correlation analysis to estimate the pairwise correlations between 90 cortical and subcortical human brain regions in normal human volunteers scanned during the post-stimulus resting state.

Cheng, Hao
Yan, Hao
Bai, Li-jun
Wang, Bao-guo
Publication Title: 
Acupuncture in Medicine: Journal of the British Medical Acupuncture Society

OBJECTIVE: While needle acupuncture is a well-accepted technique, laser acupuncture is being increasingly used in clinical practice. The differential effects of the two techniques are of interest. We examine this in relation to brain effects of activation of LR8, a putative acupuncture point for depression, using functional MRI (fMRI). METHODS: Sixteen healthy participants were randomised to receive low intensity laser acupuncture to LR8 on one side and needle acupuncture to the contralateral LR8. Stimulation was in an on-off block design and brain patterns were recorded under fMRI.

Quah-Smith, Im
Williams, Mark A.
Lundeberg, Thomas
Suo, Chao
Sachdev, Perminder
Publication Title: 
The Journal of Headache and Pain

BACKGROUND: Advanced neuroimaging approaches have been employed to prove that migraine was a central nervous system disorder. This study aims to examine resting-state abnormalities in migraine without aura (MWoA) patients stratified by disease duration, and to explore the neuroimaging markers for reflecting the disease duration. METHODS: 40 eligible MWoA patients and 20 matched healthy volunteers were included in the study.

Zhao, Ling
Liu, Jixin
Dong, Xilin
Peng, Yulin
Yuan, Kai
Wu, Fumei
Sun, Jinbo
Gong, Qiyong
Qin, Wei
Liang, Fanrong


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