Publication Title: 
Journal of Neuroimmune Pharmacology: The Official Journal of the Society on NeuroImmune Pharmacology

Acupuncture has been reported to be beneficial in treating cognitive impairment in various pathological conditions. This review describes the effort to understand the signaling pathways that underlie the acupunctural therapeutic effect on cognitive function. We searched the literature in 12 electronic databases from their inception to November 2013, with full text available and language limited to English. Twenty-three studies were identified under the selection criteria. All recruited animal studies demonstrate a significant positive effect of acupuncture on cognitive impairment.

Leung, Mason Chin Pang
Yip, Ka Keung
Ho, Yuen Shan
Siu, Flora Ka Wai
Li, Wai Chin
Garner, Belinda
Publication Title: 
Journal of Acupuncture and Meridian Studies

Acupuncture has been studied for several decades to establish evidence-based clinical practice. This systematic review aims to evaluate evidence for the effectiveness of acupuncture in influencing the functional connectivity of the central nervous system in patients with musculoskeletal pain. A systematic search of the literature was conducted to identify studies in which the central response of acupuncture in patients with musculoskeletal pain was evaluated by neuroimaging techniques.

Villarreal Santiago, María
Tumilty, Steve
M?cznik, Aleksandra
Mani, Ramakrishnan
Publication Title: 
Explore (New York, N.Y.)

OBJECTIVE: This systematic review assessed clinical evidence for the use of acupuncture as an add-on treatment in patients with depression and schizophrenia and for its underlying working mechanisms. DATA SOURCES: Four databases (Medline, Scopus, ERIC, and the Cochrane Library) were searched with a cutoff date of March 31, 2014. STUDY SELECTION: Systematic reviews and meta-analyses of acupuncture treatment for depression and schizophrenia were considered for inclusion.

Bosch, Peggy
van den Noort, Maurits
Staudte, Heike
Lim, Sabina
Publication Title: 
World Journal of Gastroenterology

In China, acupuncture has been considered an effective method for treating gastrointestinal (GI) dysfunction diseases for thousands of years. In fact, acupuncture has gained progressive acceptance from both practitioners and patients worldwide. However, the therapeutic effects and underlying mechanisms in treating GI dysfunction have not yet been established due to a lack of systematic and comprehensive review articles. Therefore, the aim of this review is to discuss the efficacy of acupuncture as a treatment for GI dysfunction and the associated underlying mechanisms.

Li, Hui
He, Tian
Xu, Qian
Li, Zhe
Liu, Yan
Li, Fang
Yang, Bo-Feng
Liu, Cun-Zhi
Publication Title: 
Scientific Reports

Acupuncture has been used for patients with stroke and post-stroke rehabilitation for thousands of years. Previous studies reported that acupuncture enhanced stroke recovery through neurogenesis. Hence, we conducted a systematic review and meta-analysis for preclinical studies to assess the current evidence for acupuncture effect on neurogenesis in treating ischaemic stroke.

Lu, Lin
Zhang, Xiao-guang
Zhong, Linda L. D.
Chen, Zi-xian
Li, Yan
Zheng, Guo-Qing
Bian, Zhao-Xiang
Publication Title: 
The Journal of Pharmacy and Pharmacology

OBJECTIVES: Withania somnifera has been in use for several thousand years in Ayurveda to treat various neurological disorders. There is, however, not much scientific data on its protective role in neuronal pathology specifically against brain oxidative stress. Hence, an attempt is made in this work for systematic review and meta-analysis of W. somnifera on neurobehavioural disorders induced by brain oxidative stress in rodents. METHODS: A systematic search of the effect of W. somnifera on brain oxidative stress-induced neuronal pathology was performed using electronic databases.

Durg, Sharanbasappa
Dhadde, Shivsharan B.
Vandal, Ravichandra
Shivakumar, Badamaranahalli S.
Charan, Chabbanahalli S.
Publication Title: 
Recent patents on CNS drug discovery

BACKGROUND: Owing to the increasing aged population globally, disorders and diseases of the CNS are anticipated to increase and profoundly impact the health care. As these neurodegenerative diseases (NDD) are complex, multifactorial and do not have identified etiological factors, unfortunately, drugs developed for the purpose have not met with the expected success. Hence, there has been a constant demand for the development of natural therapeutic adjuvants which are safe and possess the potential to attenuate multiple pathways.

Yenisetti, Sarat C.
Manjunath, M. J.
Muralidhara, C.
Publication Title: 
African journal of traditional, complementary, and alternative medicines: AJTCAM

BACKGROUND: The present study compares the protective properties of aqueous extracts of six medicinal plants, Phyllanthus emblica, Terminalia chebula (black and yellow), Terminalia arjuna, Balsamodendron Mukul and Alium sativum against lipid per-oxidation in mice brain. METHODS: The antioxidant activities were analyzed by lipid per-oxidation assay, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical assay, total antioxidant activity and metal chelation.

Khan, Asmatullah
Nazar, Halima
Sabir, Syed Mubashar
Irshad, Muhammad
Awan, Shahid Iqbal
Abbas, Rizwan
Akram, Muhammad
Khaliq, Abdul
Rocha, João Batista Texeira
Ahmad, Syed Dilnawaz
Malik, Farnaz
Publication Title: 
Mutation Research

During the course of normal respiration, reactive oxygen species are produced which are particularly detrimental to mitochondrial function. This is shown by recent studies with a mouse that lacks the mitochondrial form of superoxide dismutase (Sod2). Tissues that are heavily dependent on mitochondrial function such as the brain and heart are most severely affected in the Sod2 mutant mouse.

Melov, S.
Coskun, P. E.
Wallace, D. C.
Publication Title: 
Journal of Cell Science

In mammalian cells, products of the INK4a-ARF locus play major roles in senescence and tumour suppression in different contexts, whereas the adjacent INK4b gene is more generally associated with transforming growth factor beta (TGF-beta)-mediated growth arrest. As the chicken genome does not encode an equivalent of INK4a, we asked whether INK4b and/or ARF contribute to replicative senescence in chicken cells.

Kim, Soo-Hyun
Rowe, Janice
Fujii, Hideta
Jones, Rebecca
Schmierer, Bernhard
Kong, Byung-Whi
Kuchler, Karl
Foster, Douglas
Ish-Horowicz, David
Peters, Gordon


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