Bronchi

Publication Title: 
Medizinische Klinik (Munich, Germany: 1983)
Author(s): 
Blaha, H.
Publication Title: 
Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica

Pharmacological effects of ifenprodil (IP), 4-benzyl-alpha-(p-hydroxyphenyl)-beta-methyl-1-piperidineethanol-L-(+)-tartrate monohydrate (Funai Pharmaceutical), a potential vasodilator, were studied in the dog, rabbit, guinea-pig and mouse. 1) Intravenous administration of IP (0.1 approximately 1 mg/kg) exhibited a continuous fall in blood pressure, an increase in heart rate and an increase in cardiac contractile force in the dog. The depressor and chronotropic effects of IP appeared likewise in the pithed dog, and the depressor responses were slightly more evident in the rabbit.

Author(s): 
Maeda, Y.
Furukawa, T.
Publication Title: 
PloS One

BACKGROUND: Phosphoinositide 3-kinase (PI3K)/Akt pathway is linked to the development of asthma. Anti-malarial drug artesunate is a semi-synthetic derivative of artemisinin, the principal active component of a medicinal plant Artemisia annua, and has been shown to inhibit PI3K/Akt activity. We hypothesized that artesunate may attenuate allergic asthma via inhibition of the PI3K/Akt signaling pathway. METHODOLOGY/PRINCIPAL FINDINGS: Female BALB/c mice sensitized and challenged with ovalbumin (OVA) developed airway inflammation.

Author(s): 
Cheng, Chang
Ho, W. Eugene
Goh, Fera Y.
Guan, Shou Ping
Kong, Li Ren
Lai, Wen-Qi
Leung, Bernard P.
Wong, W. S. Fred
Publication Title: 
The Journal of Asthma: Official Journal of the Association for the Care of Asthma

After an initial integrated yoga training program of 2 to 4 weeks, 570 bronchial asthmatics were followed up for 3 to 54 months. The training consisted of yoga practices--yogasanas, Pranayama, meditation, and kriyas--and theory of yoga. Results show highly significant improvement in most of the specific parameters. The regular practitioners showed the greatest improvement.

Author(s): 
Nagendra, H. R.
Nagarathna, R.
Publication Title: 
The Journal of the Association of Physicians of India

Air flowing through a pipe exerts frictional stress on the walls of the pipe. Frictional stress of more than 40 N/m2 (velocity equivalent of air 113 m/s) is known to cause acute endothelial damage in blood vessels. The frictional stress in airways during coughing may be much greater, however, since the velocity of air may be as high as speed of sound in air. We suggest that high levels of frictional stress perpetuate airway inflammation in airways which are already inflamed and vulnerable to frictional stress-induced trauma in patients with asthma.

Author(s): 
Singh, V.
Chowdhary, R.
Chowdhary, N.
Publication Title: 
The Journal of the Association of Physicians of India

Air flowing through a pipe exerts frictional stress on the walls of the pipe. Frictional stress of more than 40 N/m2 (velocity equivalent of air 113 m/s) is known to cause acute endothelial damage in blood vessels. The frictional stress in airways during coughing may be much greater, however, since the velocity of air may be as high as speed of sound in air. We suggest that high levels of frictional stress perpetuate airway inflammation in airways which are already inflamed and vulnerable to frictional stress-induced trauma in patients with asthma.

Author(s): 
Singh, V.
Chowdhary, R.
Chowdhary, N.
Publication Title: 
American Journal of Physiology. Lung Cellular and Molecular Physiology

Activation of an innate immune response in airway epithelia by the human pathogen Pseudomonas aeruginosa requires bacterial expression of flagellin. Addition of flagellin (10(-7) M) to airway epithelial cell monolayers (Calu-3, airway serous cell-like) increased Cl(-) secretion (I(Cl)) beginning after 3-10 min, reaching a plateau after 20-45 min at DeltaI(Cl) = 15-50 microA/cm(2). Similar, although 10-fold smaller, responses were observed in well-differentiated bronchial epithelial cultures.

Author(s): 
Illek, Beate
Fu, Zhu
Schwarzer, Christian
Banzon, Tina
Jalickee, Stephen
Miller, Sheldon S.
Machen, Terry E.
Publication Title: 
Cellular Physiology and Biochemistry: International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology

Little is known about the relationship between CF transmembrane conductance regulator (CFTR) gene expression and the corresponding transport of Cl. The phenotypic characteristics of polarized DeltaF508 homozygote CF bronchial epithelial (CFBE41o-) cells were evaluated following transfection with episomal expression vector containing either full-length (6.2kb) wild type (wt) and (4.7kb) DeltaF508CFTR cDNA.

Author(s): 
Illek, Beate
Maurisse, Rosalie
Wahler, Logan
Kunzelmann, Karl
Fischer, Horst
Gruenert, Dieter C.
Publication Title: 
Free Radical Biology & Medicine

Pyocyanin (N-methyl-1-hydroxyphenazine), a redox-active virulence factor produced by the human pathogen Pseudomonas aeruginosa, is known to compromise mucociliary clearance. Exposure of human bronchial epithelial cells to pyocyanin increased the rate of cellular release of H(2)O(2) threefold above the endogenous H(2)O(2) production.

Author(s): 
Schwarzer, Christian
Fischer, Horst
Kim, Eun-Jin
Barber, Katharine J.
Mills, Aaron D.
Kurth, Mark J.
Gruenert, Dieter C.
Suh, Jung H.
Machen, Terry E.
Illek, Beate
Publication Title: 
American Journal of Respiratory and Critical Care Medicine

RATIONALE: Airway inflammation is a central feature of chronic obstructive pulmonary disease (COPD). COPD exacerbations are often triggered by rhinovirus (RV) infection. OBJECTIVES: We hypothesized that airway epithelial cells from patients with COPD maintain a proinflammatory phenotype compared with control subjects, leading to greater RV responses. METHODS: Cells were isolated from tracheobronchial tissues of 12 patients with COPD and 10 transplant donors. Eight patients with COPD had severe emphysema, three had mild to moderate emphysema, and one had no emphysema.

Author(s): 
Schneider, Dina
Ganesan, Shyamala
Comstock, Adam T.
Meldrum, Catherine A.
Mahidhara, Raja
Goldsmith, Adam M.
Curtis, Jeffrey L.
Martinez, Fernando J.
Hershenson, Marc B.
Sajjan, Umadevi

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