C-Peptide

Publication Title: 
Diabetes & Metabolic Syndrome

STATEMENT OF THE PROBLEM: Complementary and alternative medicines have been increasingly used as a co adjuvant treatment of chronic diseases, including diabetes mellitus. However, very little is known, especially in western countries, about its effects in the treatment of type 2 diabetes mellitus (T2DM). The purpose of this review was to summarize and critically evaluate clinical evidences regarding the effect of Chinese therapeutic exercises (Qigong) in the treatment of T2DM.

Author(s): 
Freire, Marcos Dantas Moraes
Alves, Cresio
Publication Title: 
International Journal of Obesity (2005)

OBJECTIVE: With the increasing rates of obesity, many people diet in an attempt to lose weight. As weight loss is seldom maintained in a single effort, weight cycling is a common occurrence. Unfortunately, reports from clinical studies that have attempted to determine the effect of weight cycling on mortality are in disagreement, and to date, no controlled animal study has been performed to assess the impact of weight cycling on longevity.

Author(s): 
List, E. O.
Berryman, D. E.
Wright-Piekarski, J.
Jara, A.
Funk, K.
Kopchick, J. J.
Publication Title: 
The Journal of Nutrition

This study assessed the effect of oral pinitol supplementation on oral and intravenous glucose tolerances and on skeletal muscle insulin receptor content and phosphorylation in older people. Fifteen people (6 men, 9 women; age 66 +/- 8 y; BMI 27.9 +/- 3.3 kg/m(2); hemoglobin A1c 5.39 +/- 0.46%, mean +/- SD) completed a 7-wk protocol. Subjects were randomly assigned to groups that during wk 2-7 consumed twice daily either a non-nutritive beverage (Placebo group, n = 8) or the same beverage with 1000 mg pinitol dissolved into it (Pinitol group, n = 7, total dose = 2000 mg pinitol/d).

Author(s): 
Campbell, Wayne W.
Haub, Mark D.
Fluckey, James D.
Ostlund, Richard E.
Thyfault, John P.
Morse-Carrithers, Hannah
Hulver, Matthew W.
Birge, Zonda K.
Publication Title: 
Metabolism: Clinical and Experimental

Intravenous glucose tolerance tests have demonstrated lower whole-body insulin sensitivity (S(I)) among African Americans (AA) compared with European Americans (EA). Whole-body S(I) represents both insulin-stimulated glucose disposal, primarily by skeletal muscle, and insulin's suppression of endogenous glucose production (EGP) by liver. A mathematical model was recently introduced that allows for distinction between disposal and hepatic S(I).

Author(s): 
Ellis, Amy C.
Alvarez, Jessica A.
Granger, Wesley M.
Ovalle, Fernando
Gower, Barbara A.
Publication Title: 
Current Diabetes Reviews

Pancreatic β-cell dysfunction plays an important role in the pathogenesis of both type 1 and type 2 diabetes. Insulin, which is produced in β-cells, is a critical regulator of metabolism. Insulin is synthesized as preproinsulin and processed to proinsulin. Proinsulin is then converted to insulin and C-peptide and stored in secretary granules awaiting release on demand. Insulin synthesis is regulated at both the transcriptional and translational level.

Author(s): 
Fu, Zhuo
Gilbert, Elizabeth R.
Liu, Dongmin
Publication Title: 
Biochemical and Biophysical Research Communications

This initial report presents a neonatal rat model with exposure to a transient intermittent hypoxia (IH), which results in a persisting diabetes-like condition in the young rats. Twenty-five male pups were treated at postnatal day 1 with IH exposure by alternating the level of oxygen between 10.3% and 20.8% for 5h. The treated animals were then maintained in normal ambient oxygen condition for 3 week and compared to age-matched controls. The IH treated animals exhibited a significantly higher fasting glucose level than the control animals (237.00 ± 19.66 mg/dL vs.

Author(s): 
Pae, Eung-Kwon
Ahuja, Bhoomika
Kim, Marieyerie
Kim, Gyuyoup
Publication Title: 
Diabetes Care

OBJECTIVE: To examine after gastric bypass the effect of peroral versus gastroduodenal feeding on glucose metabolism. RESEARCH DESIGN AND METHODS: A type 2 diabetic patient was examined on 2 consecutive days 5 weeks after gastric bypass. A standard liquid meal was given on the first day into the bypassed gastric remnant and on the second day perorally. Plasma glucose, insulin, C-peptide, glucagon, incretin hormones, peptide YY, and free fatty acids were measured. RESULTS: Peroral feeding reduced 2-h postprandial plasma glucose (7.8 vs.

Author(s): 
Dirksen, Carsten
Hansen, Dorte L.
Madsbad, Sten
Hvolris, Lisbeth E.
Naver, Lars S.
Holst, Jens J.
Worm, Dorte
Publication Title: 
Diabetes & Metabolic Syndrome

STATEMENT OF THE PROBLEM: Complementary and alternative medicines have been increasingly used as a co adjuvant treatment of chronic diseases, including diabetes mellitus. However, very little is known, especially in western countries, about its effects in the treatment of type 2 diabetes mellitus (T2DM). The purpose of this review was to summarize and critically evaluate clinical evidences regarding the effect of Chinese therapeutic exercises (Qigong) in the treatment of T2DM.

Author(s): 
Freire, Marcos Dantas Moraes
Alves, Cresio
Publication Title: 
Zhong Yao Cai = Zhongyaocai = Journal of Chinese Medicinal Materials

OBJECTIVE: To observe the effects of Astragalus polysaccharides (APS) on the BG, insulin and C-peptide in serum, ultrastructure and Fas expression of pancreatic beta-cells in diabetes mellitus (DM) rats. METHODS: Thirty DM rats induced by streptozotocin (STZ) were randomly divided into three groups: DM group, APS 200 mg/kg group, APS 400 mg/kg group, another 10 normal rats were taken as the control group. The drug was given by intraperitoneal for 6 weeks. The level of BG was determined by ONE TOUCH II machine. The levels of insulin and C-peptide in serum were measured by radioimmunoassay.

Author(s): 
Li, Cheng-De
Li, Jing-Jing
Wang, Lin
Wang, Jin-Hong
Dai, Gong
Kang, Bai
Mao, Shu-Mei
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