Carbon Monoxide Poisoning

Publication Title: 
American Journal of Physiology. Heart and Circulatory Physiology

Studies were conducted with rats to investigate whether platelet activating factor (PAF) and nitric oxide (*NO)-derived oxidants played roles in the initial adherence of neutrophils to vasculature in the brain after carbon monoxide (CO) poisoning. Before CO poisoning, rats were treated with the competitive PAF receptor antagonist WEB-2170 or with the peroxynitrite scavenger selenomethionine. Both agents caused significantly lower concentrations of myeloperoxidase in the brain after poisoning, indicating fewer sequestered neutrophils.

Author(s): 
Thom, S. R.
Fisher, D.
Manevich, Y.
Publication Title: 
Proceedings of the National Academy of Sciences of the United States of America

The neuropathological sequelae of carbon monoxide (CO) poisoning cannot be explained by hypoxic stress alone. CO poisoning also causes adduct formation between myelin basic protein (MBP) and malonylaldehyde, a reactive product of lipid peroxidation, resulting in an immunological cascade. MBP loses its normal cationic characteristics, and antibody recognition of MBP is altered. Immunohistochemical evidence of degraded MBP occurs in brain over days, along with influx of macrophages and CD-4 lymphocytes.

Author(s): 
Thom, Stephen R.
Bhopale, Veena M.
Fisher, Donald
Zhang, Jie
Gimotty, Phyllis
Publication Title: 
American Journal of Respiratory and Critical Care Medicine

RATIONALE: We hypothesized that platelet-neutrophil interactions occur as a result of acute carbon monoxide (CO) poisoning, and subsequent neutrophil activation triggers events that cause neurologic sequelae. OBJECTIVES: To identify platelet-neutrophil interactions and neutrophil activation in patients and in animal models, and to establish the association between these intravascular events and changes linked to CO-mediated neurologic sequelae in an animal model. MEASUREMENTS AND MAIN RESULTS: Blood was obtained from 50 consecutive patients.

Author(s): 
Thom, Stephen R.
Bhopale, Veena M.
Han, Shih-Tsung
Clark, James M.
Hardy, Kevin R.
Publication Title: 
Toxicology Letters

Neurological sequelae (NS) is a common complication of carbon monoxide (CO) poisoning and structural alterations of myelin basic protein have been proven to initiate immunological reactions leading to NS. To determine whether xanthine oxidoreductase (XOR) participates in the pathophysiology of CO-mediated NS, we examined myelin basic protein in CO poisoned XOR-depleted rats and performed radial maze studies to evaluate the alteration of cognitive function.

Author(s): 
Han, Shih-Tsung
Bhopale, Veena M.
Thom, Stephen R.
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