Cardiomyopathy, Dilated

Publication Title: 
Disease Models & Mechanisms

Cardiac fibrosis is critically involved in the adverse remodeling accompanying dilated cardiomyopathies (DCMs), which leads to cardiac dysfunction and heart failure (HF). Connective tissue growth factor (CTGF), a profibrotic cytokine, plays a key role in this deleterious process. Some beneficial effects of IGF1 on cardiomyopathy have been described, but its potential role in improving DCM is less well characterized.

Touvron, Melissa
Escoubet, Brigitte
Mericskay, Mathias
Angelini, Aude
Lamotte, Luciane
Santini, Maria Paola
Rosenthal, Nadia
Daegelen, Dominique
Tuil, David
Decaux, Jean-FranÁois
Publication Title: 
Die Pharmazie

Nardostachys jatamansi is a medicinally important herb of Indian origin used for centuries in Ayurvedic and Unani systems of medicine for the treatment of various ailments. The aim of the present work is to evaluate the effect of ethanolic extract of Nardostachys jatamansi rhizomes on doxorubicin induced myocardial injury with respect to lipid metabolism in serum and heart of Wistar albino rats. Altered lipid metabolism alters the cardiac function which is mainly due to changes in the property of the cardiac cell membrane.

Subashini, R.
Ragavendran, B.
Gnanapragasam, A.
Yogeeta, S. Kumar
Devaki, T.
Publication Title: 
Indian Journal of Medical Sciences

BACKGROUND: Dilated cardiomyopathy (DCM) still remains to be a poorly understood and less analyzed group of cardiac-muscle disorders when compared to hypertrophic cardiomyopathy (HCM). Also, the vast clinical heterogeneity among the patients has rendered the small and isolated kindred studies less informative on the genetics and epidemiology of DCM. AIM OF THE STUDY: The study aimed at understanding the epidemiology and genetics of DCMs in the Indian context.

Ushasree, B.
Shivani, V.
Venkateshwari, A.
Jain, R. K.
Narsimhan, C.
Nallari, Pratibha
Publication Title: 
PloS One

BACKGROUND: Despite remarkable progress in treatment of chronic heart failure (CHF) over the last two decades, mortality, personal suffering and cost remain staggering, and effective interventions are still a challenge. Previously we reported that a blueberry-enriched diet (BD) attenuated necroapoptosis and inflammation in periinfarct area in a rat model of myocardial infarction (MI). OBJECTIVES: To test the hypothesis that BD will attenuate the course of CHF, including mortality and cardiac remodeling during the first year after induction of MI in rats.

Ahmet, Ismayil
Spangler, Edward
Shukitt-Hale, Barbara
Joseph, James A.
Ingram, Donald K.
Talan, Mark
Publication Title: 
PloS One

BACKGROUND: Duchenne muscular dystrophy (DMD) is the most common, lethal disease of childhood. One of 3500 new-born males suffers from this universally-lethal disease. Other than the use of corticosteroids, little is available to affect the relentless progress of the disease, leading many families to use dietary supplements in hopes of reducing the progression or severity of muscle wasting. Arginine is commonly used as a dietary supplement and its use has been reported to have beneficial effects following short-term administration to mdx mice, a genetic model of DMD.

Wehling-Henricks, Michelle
Jordan, Maria C.
Gotoh, Tomomi
Grody, Wayne W.
Roos, Kenneth P.
Tidball, James G.
Publication Title: 
American Journal of Medical Genetics. Part A

Alström syndrome (AS; OMIM 203800) is an autosomal recessive disorder characterized by cone-rod dystrophy, dilated cardiomyopathy, sensorineural hearing impairment, developmental delay, and most case had both childhood-onset obesity and hyperinsulinemia. Currently, the pathogenesis of this disease is not clear. Here we report on an 18-month-old boy with Alström syndrome. He had obesity but with normal insulin and glucose levels. Molecular analysis of the ALMS1 gene revealed a 19 base pair homozygous deletion 11116_11134del in exon 16.

Lee, Ni-Chung
Marshall, Jan D.
Collin, Gayle B.
Naggert, Jürgen K.
Chien, Yin-Hsiu
Tsai, Wen-Yu
Hwu, Wuh-Liang
Publication Title: 
Journal of Cardiac Surgery

We report a case of spontaneous vertebral artery dissection (VAD) in a patient who developed extensive subcutaneous emphysema following the removal of a chest tube after a cardiac transplant. The pathophysiology and management of this uncommon complication are reviewed. Although vertebral and carotid artery dissections are unusual events occurring in 2.5 to 3 per 100,000 people, they are increasingly acknowledged to be important causes of stroke in the young and middle-aged adult population accounting for up to 25% of such cases.

Rabkin, David G.
Benharash, Peyman
Shemin, Richard J.
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