Cell Movement

Publication Title: 
Molecules (Basel, Switzerland)

Astragaloside IV (AS-IV), one of the major active constituents of Astragalus membranaceus in Traditional Chinese Medicine, has been widely used to treat ischemic diseases. However, the potential mechanism is this action is unclear. In this study, we tested the hypothesis that AS-IV might promote angiogenesis through multiple signaling pathways. Our data indicate that AS-IV treatment promotes umbilical vein endothelial cells (HUVEC) proliferation, migration, and tube formation.

Author(s): 
Wang, Shi-Guang
Xu, Yan
Chen, Jian-Dong
Yang, Chuan-Hua
Chen, Xiao-Hu
Publication Title: 
Diagnostic Pathology

BACKGROUND: Astragalus memebranaceus is a traditional Chinese herbal medicine used in treatment of common cold, diarrhea, fatigue, anorexia and cardiac diseases. Recently, there are growing evidences that Astragalus extract may be a potential anti-tumorigenic agent. Some research showed that the total saponins obtained from Astragalus membranaceus possess significant antitumorigenic activity. Gastric cancer is one of the most frequent cancers in the world, almost two-thirds of gastric cancer cases and deaths occur in less developed regions.

Author(s): 
Wang, Tao
Xuan, Xiaoyan
Li, Min
Gao, Ping
Zheng, Yuling
Zang, Wenqiao
Zhao, Guoqiang
Publication Title: 
PloS One

Cell adhesion, migration and invasion are critical steps for carcinogenesis and cancer metastasis. Ganoderma lucidum, also called Lingzhi in China, is a traditional Chinese medicine, which exhibits anti-proliferation, anti-inflammation and anti-metastasis properties. Herein, GAEE, G. lucidum extract mainly contains ganoderiol A (GA), dihydrogenated GA and GA isomer, was shown to inhibit the abilities of adhesion and migration, while have a slight influence on that of invasion in highly metastatic breast cancer MDA-MB-231 cells at non-toxic doses.

Author(s): 
Wu, Guo-Sheng
Song, Yue-Lin
Yin, Zhi-Qi
Guo, Jia-Jie
Wang, Sheng-Peng
Zhao, Wen-Wen
Chen, Xiu-Ping
Zhang, Qing-Wen
Lu, Jin-Jian
Wang, Yi-Tao
Publication Title: 
PloS One

Bamboo shavings (Bambusae Caulis in Taeniam, BCT) are widely used as a traditional Chinese medicine to control hypertension and cardiovascular disease, and to alleviate fever, vomiting, and diarrhea. It has been demonstrated that BCT reduces ovalbumin-induced airway inflammation by regulating pro-inflammatory cytokines, and decreases tumor growth in tumor-bearing mice. However, the effects of BCT on the metastatic potential of malignant cancer cells and the detailed mechanism of its anti-metastatic activity have not been examined previously.

Author(s): 
Kim, Aeyung
Im, Minju
Yim, Nam-Hui
Jung, Young Pil
Ma, Jin Yeul
Publication Title: 
International Journal of Cancer. Journal International Du Cancer

Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal malignancies characterized by an intense tumor stroma with hypoperfused regions, a significant inflammatory response and pronounced therapy resistance. New therapeutic agents are urgently needed. The plant-derived agent triptolide also known as "thunder god vine" has a long history in traditional Chinese medicine for treatment of rheumatoid arthritis and cancer and is now in a clinical phase II trial for establishing the efficacy against a placebo.

Author(s): 
Liu, Li
Salnikov, Alexei V.
Bauer, Nathalie
Aleksandrowicz, Ewa
Labsch, Sabrina
Nwaeburu, Clifford
Mattern, Jürgen
Gladkich, Jury
Schemmer, Peter
Werner, Jens
Herr, Ingrid
Publication Title: 
Cell Cycle (Georgetown, Tex.)

CDK8 is either amplified or mutated in a variety of human cancers, and CDK8 functions as an oncoprotein in melanoma and colorectal cancers. Previously, we reported that loss or reduction of CDK8 results in aberrant fat accumulation in Drosophila and mammals, suggesting that CDK8 plays an important role in inhibiting lipogenesis.

Author(s): 
Gu, Weiting
Wang, Chenguang
Li, Weihua
Hsu, Fu-Ning
Tian, Lifeng
Zhou, Jie
Yuan, Cunzhong
Xie, Xiao-Jun
Jiang, Tao
Addya, Sankar
Tai, Yanhong
Kong, Beihua
Ji, Jun-yuan
Publication Title: 
Cellular Physiology and Biochemistry: International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology

The antitumor effects of external Qi of Yan Xin Qigong (YXQ-EQ) have been widely described over the past three decades. To gain a better understanding of the mechanisms underlying YXQ-EQ's antitumor effects, in the present study we investigated its effects on growth, migration, invasion and apoptosis of breast cancer cells and the underlying molecular mechanisms. We show that YXQ-EQ treatment caused a time-dependent reduction in viability, blocked clonogenic growth and induced apoptosis in estrogen-independent breast cancer MDA-MB-231 cells.

Author(s): 
Yan, Xin
Shen, Hua
Jiang, Hongjian
Hu, Dan
Zhang, Chengsheng
Wang, Jun
Wu, Xinqi
Publication Title: 
Molecular and Cellular Biochemistry

Small-cell lung cancer (SCLC) is a highly malignant carcinoma with poor long-term survival. Effective treatment remains highly demanded. In the present study, we demonstrated that External Qi of Yan Xin Qigong (YXQ-EQ) exerted potent cytotoxic effect towards SCLC cell line NCI-H82 via induction of apoptosis. Global gene expression profiling identified 39 genes whose expression was altered by YXQ-EQ in NCI-82 cells.

Author(s): 
Yan, Xin
Li, Feng
Dozmorov, Igor
Frank, Mark Barton
Dao, Ming
Centola, Michael
Cao, Wei
Hu, Dan
Publication Title: 
Biological & Pharmaceutical Bulletin

Angiogenesis consists of the proliferation, migration, and differentiation of endothelial cells, and angiogenic factors and matrix protein interactions modulate this process. The aim of this study was to determine the angiogenic properties of Uncaria rhynchophylla. Uncaria rhynchophylla significantly enhanced human umbilical vein endothelial cells (HUVECs) proliferation in a dose-dependent manner.

Author(s): 
Choi, Do-Young
Huh, Jeong-Eun
Lee, Jae-Dong
Cho, Eun-Mi
Baek, Yong-Hyeon
Yang, Ha-Ru
Cho, Yoon-Je
Kim, Kang-Il
Kim, Deog-Yoon
Park, Dong-Suk

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