Cell Movement

Publication Title: 
In Vivo (Athens, Greece)

A new approach to cancer therapy in recent years has been to target the metastatic process. The anti-metastatic potential of curcusone B, a diterpene isolated from Jatropha curcas Linn. (Euphorbiaceae), a herbal plant that has been used in traditional folk medicine in many tropical countries, was investigated against 4 human cancer cell lines.

Author(s): 
Muangman, Surin
Thippornwong, Montri
Tohtong, Rutaiwan
Publication Title: 
The Journal of Pharmacology and Experimental Therapeutics

Tumor-induced angiogenesis is essential for invasive growth and hematogenous metastasis of adenoid cystic carcinoma (ACC), a highly aggressive neoplasm mostly occurring in salivary glands. Previous studies have indicated that strategies directed against angiogenesis will help develop new therapeutic agents for ACC. The Chinese folk medicine licorice has been used for years as a natural remedy for angiogenesis-related diseases.

Author(s): 
Sun, Zhi-Jun
Chen, Gang
Zhang, Wei
Hu, Xiang
Huang, Cong-Fa
Wang, Yu-Fan
Jia, Jun
Zhao, Yi-Fang
Publication Title: 
Journal of Ethnopharmacology

AIM OF THE STUDY: Species of Lychnophora are used in Brazilian folk medicine as analgesic and anti-inflammatory agents. Chlorogenic acid (CGA) and their analogues are important components of polar extracts of these species, as well in several European and Asian medicinal plants. Some of these phenolic compounds display anti-inflammatory effects. In this paper we report the isolation of CGA from Lychnophora salicifolia and its effects on functions involved in neutrophils locomotion. MATERIALS AND METHODS: LC-MS(n) data confirmed the presence of CGA in the plant.

Author(s): 
Hebeda, C. B.
Bolonheis, S. M.
Nakasato, A.
Belinati, K.
Souza, P. D. C.
Gouvea, D. R.
Lopes, N. P.
Farsky, S. H. P.
Publication Title: 
Journal of Medicinal Food

Atherosclerosis is a chronic and progressive inflammatory disease. Novel anti-inflammatory therapies may have promise as treatment strategies for cardiovascular risk reduction. Rosemary (Rosemarinus officinalis L.) has been used in folk medicine to treat headaches, epilepsy, poor circulation, and many other ailments. It was found that rosemary could act as a stimulant and mild analgesic and could reduce inflammation. However, the mechanisms underlying the anti-inflammatory and antiatherosclerotic effects of rosemary need more study.

Author(s): 
Chae, In Gyeong
Yu, Mi Hee
Im, Nam-Kyung
Jung, Young Tae
Lee, Jinho
Chun, Kyung-Soo
Lee, In-Seon
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Teas from the husk fiber of Cocos nucifera are used in the folk medicine to treat arthritis and other inflammatory processes. Some works show that some varieties have biological activities. However, one of the main variety of the species, C. nucifera var. typica, known in Brazil as "gigante", was not studied yet. Thus, this study evaluates if this variety has the anti-inflammatory and antimicrobial activities already reported in other varieties. METHODS: C.

Author(s): 
Silva, Rafaela Ribeiro
Oliveira e Silva, Davi
Fontes, Humberto Rollemberg
Alviano, Celuta Sales
Fernandes, Patricia Dias
Alviano, Daniela Sales
Publication Title: 
Molecules (Basel, Switzerland)

Baccharis trimera is used in folk medicine as a tea for digestive and liver diseases. It possesses anti-inflammatory and antioxidant properties that are related to the presence of phenolic compounds. The aim of this work was to investigate the anti-proliferative properties of phenolic (PHE) and terpenoid (SAP) compounds from B. trimera on human cervical cancer. The treatment of SiHa cells with PHE for 24 h suppressed colony formation in a dose-dependent manner, inhibited proliferation and inhibited cell motility.

Author(s): 
de Oliveira, Cristiane B.
Comunello, Lucimara N.
Maciel, Erica S.
Giubel, Scheron R.
Bruno, Alessandra N.
Chiela, Eduardo C. F.
Lenz, Guido
Gnoatto, Simone C. B.
Buffon, Andréia
Gosmann, Grace
Publication Title: 
The Journal of Biological Chemistry

Fibroblast growth factors are key proteins in many intercellular signaling networks. They normally remain attached to the extracellular matrix, which confers on them a considerable stability. The unrestrained accumulation of fibroblast growth factors in the extracellular milieu, either due to uncontrolled synthesis or enzymatic release, contributes to the pathology of many diseases. Consequently, the neutralization of improperly mobilized fibroblast growth factors is of clear therapeutic interest.

Author(s): 
Fernández, Israel S.
Cuevas, Pedro
Angulo, Javier
López-Navajas, Pilar
Canales-Mayordomo, Angeles
González-Corrochano, Rocío
Lozano, Rosa M.
Valverde, Serafín
Jiménez-Barbero, Jesús
Romero, Antonio
Giménez-Gallego, Guillermo
Publication Title: 
Carcinogenesis

Grape seed extract (GSE) is a widely consumed dietary supplement that has antitumor activity. Here, we have investigated the inhibitory effect of GSE on the expression of vascular endothelial growth factor (VEGF) and the mechanism underlying this action. We found that GSE inhibited VEGF messenger RNA (mRNA) and protein expression in U251 human glioma cells and MDA-MB-231 human breast cancer cells. GSE inhibited transcriptional activation of the VEGF gene through reducing protein but not mRNA expression of hypoxia-inducible factor (HIF) 1alpha.

Author(s): 
Lu, Jianming
Zhang, Keqiang
Chen, Shiuan
Wen, Wei
Publication Title: 
Cancer Prevention Research (Philadelphia, Pa.)

Blockade of angiogenesis is an important approach for cancer treatment and prevention. Vascular endothelial growth factor (VEGF) is one of the most critical factors that induce angiogenesis and has thus become an attractive target for antiangiogenesis treatment. However, most current anti-VEGF agents often cause some side effects when given chronically. Identification of naturally occurring VEGF inhibitors derived from diet would be one alternative approach with an advantage of known safety. Grape seed extract (GSE), a widely used dietary supplement, is known to have antitumor activity.

Author(s): 
Wen, Wei
Lu, Jianming
Zhang, Keqiang
Chen, Shiuan
Publication Title: 
International Journal of Oncology

Expression and activity of CC motif ligand 2 (CCL2) is down-regulated by curcumin, the active phytochemical ingredient of turmeric (Curcuma longa), a dietary supplement often self-prescribed to promote prostate health. CCL2 is a potent chemotactic factor of prostate cancer (PCa) with important roles in development of bone metastasis. The relationship between CCL2 and curcumin, however, has not been studied in PCa. Adhesion, invasion and motility of PC-3 cells were measured in response to exposure to curcumin (30 microM; 18 h), CCL2 (100 ng/ml; 18 h) or PMA (100 ng/ml; 18 h).

Author(s): 
Herman, Jeffery G.
Stadelman, Henry L.
Roselli, Charles E.

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