Cognitive impairment

Publication Title: 
Restorative Neurology and Neuroscience

PURPOSE: Cognitive impairment is one of the most disabling symptoms of multiple sclerosis (MS), affecting a large proportion of patients and having a severe impact on their quality of life. Nevertheless, there exists a large variability in the neuropsychological profiles of MS patients and some of them appear to withstand better than others the MS-related brain pathology before showing cognitive decline.

Author(s): 
Crescentini, Cristiano
Urgesi, Cosimo
Fabbro, Franco
Eleopra, Roberto
Publication Title: 
Restorative Neurology and Neuroscience

PURPOSE: Cognitive impairment is one of the most disabling symptoms of multiple sclerosis (MS), affecting a large proportion of patients and having a severe impact on their quality of life. Nevertheless, there exists a large variability in the neuropsychological profiles of MS patients and some of them appear to withstand better than others the MS-related brain pathology before showing cognitive decline.

Author(s): 
Crescentini, Cristiano
Urgesi, Cosimo
Fabbro, Franco
Eleopra, Roberto
Publication Title: 
Journal of Psychiatric Research

Common variants of the FK506 binding protein 5 (FKBP5) gene are implicated in psychotic and other disorders, via their role in regulating glucocorticoid receptor (GR) receptor sensitivity and effects on the broader function of the HPA system in response to stress.

Author(s): 
Green, Melissa J.
Raudino, Alessandra
Cairns, Murray J.
Wu, Jingqin
Tooney, Paul A.
Scott, Rodney J.
Carr, Vaughan J.
Australian Schizophrenia Research Bank
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