Cohort Studies

Publication Title: 
The British Journal of Nutrition

Epidemiological studies show that adherence to a Mediterranean diet (MD) increases longevity; however, few studies are restricted to Mediterranean populations or explore the effect of a MD pattern that directly incorporates olive oil. Therefore the relationship between adherence to the MD and mortality was studied within the the Spanish cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Spain). The EPIC-Spain analysis included 40 622 participants (37∑7†% males) aged 29-69 years who were recruited from five Spanish regions in 1992-1996.

Buckland, Genevieve
Agudo, Antonio
Travier, Noemie
Huerta, JosÈ MarÌa
Cirera, LluÌs
Tormo, MarÌa-JosÈ
Navarro, Carmen
Chirlaque, MarÌa Dolores
Moreno-Iribas, Conchi
Ardanaz, Eva
Barricarte, Aurelio
Etxeberria, Jaione
Marin, Pilar
QuirÛs, J. RamÛn
Redondo, MarÌa-Luisa
LarraÒaga, Nerea
Amiano, Pilar
Dorronsoro, Miren
Arriola, Larraitz
Basterretxea, Mikel
Sanchez, MarÌa-JosÈ
Molina, Esther
Gonz·lez, Carlos A.
Publication Title: 
Journal of the American Geriatrics Society

OBJECTIVES: To assess lifestyle factors including physical activity, smoking, alcohol consumption, and dietary habits in men and women with exceptional longevity. DESIGN: Retrospective cohort study. SETTING: A cohort of community-dwelling Ashkenazi Jewish individuals with exceptional longevity defined as survival and living independently at age 95 and older.

Rajpathak, Swapnil N.
Liu, Yingheng
Ben-David, Orit
Reddy, Saritha
Atzmon, Gil
Crandall, Jill
Barzilai, Nir
Publication Title: 
The Journal of Nutrition, Health & Aging

BACKGROUND: Despite many studies on cognitive function and its influential factors among old population, relatively little research has been designed to study the relationship between dietary intake and cognitive function in elderly. OBJECTIVE: We conducted a population-based, prospective nested case-control study to investigate the association between dietary habits and declines in cognitive function over three years among Chinese illiterate elderly. DESIGN AND METHODS: This study was part of the Chinese Longitudinal Health Longevity Study (CLHLS).

Chen, X.
Huang, Y.
Cheng, H. G.
Publication Title: 
The Journal of Nutrition

Dietary guidelines generally recommend avoiding a high-fat diet. However, the relationship between fat subtypes and mortality remains unclear especially in a population with a relatively low intake of fat. We aimed to prospectively examine the relationship between dietary fat intake and all-cause and cause-specific mortality in a Japanese community. In 1992, a total of 28,356 residents of Takayama, Japan, without cancer, stroke, or coronary heart disease, responded to a validated 169-item FFQ. We identified 4616 deaths during a 16-y follow-up.

Nagata, Chisato
Nakamura, Kozue
Wada, Keiko
Oba, Shino
Tsuji, Michiko
Tamai, Yuya
Kawachi, Toshiaki
Publication Title: 
Health and Quality of Life Outcomes

BACKGROUND: Nutrition and physical activity are major determinants of health and quality of life; however, there exists little research focusing on determinants of these behaviours in older adults. This is important, since just as these behaviours vary according to subpopulation, it is likely that the determinants also vary.

McNaughton, Sarah A.
Crawford, David
Ball, Kylie
Salmon, Jo
Publication Title: 
Veterinary surgery: VS

OBJECTIVE: To determine the chronology of radiographic signs of canine hip dysplasia (CHD), specifically joint laxity and secondary osteoarthritis (OA). STUDY DESIGN: Longitudinal cohort study. ANIMALS: Paired littermates, 48 Labrador retrievers. METHODS: Conventional, ventrodorsal, hip-extended (HE) radiographs were evaluated yearly for CHD according to the subjective criteria of the Orthopedic Foundation for Animals (OFA). PennHIP screening was performed at 2 years of age to assess joint laxity by distraction index (DI).

Smith, Gail K.
Lawler, Dennis F.
Biery, Darryl N.
Powers, Michelle Y.
Shofer, Frances
Gregor, Thomas P.
Karbe, Georga T.
McDonald-Lynch, Mischa B.
Evans, Richard H.
Kealy, Richard D.
Publication Title: 
PloS One

BACKGROUND: A Mediterranean diet has a recognized beneficial effect on health and longevity, with a protective influence on several cancers. However, its association with breast cancer risk remains unclear. OBJECTIVE: We aimed to investigate whether adherence to a Mediterranean dietary pattern influences breast cancer risk. DESIGN: The Swedish Women's Lifestyle and Health cohort study includes 49,258 women aged 30 to 49 years at recruitment in 1991-1992. Consumption of foods and beverages was measured at enrollment using a food frequency questionnaire.

Couto, Elisabeth
Sandin, Sven
Lˆf, Marie
Ursin, Giske
Adami, Hans-Olov
Weiderpass, Elisabete
Publication Title: 
The American Journal of Clinical Nutrition

BACKGROUND: In 2007, the World Cancer Research Fund (WCRF) and the American Institute for Cancer Research (AICR) issued recommendations on diet, physical activity, and weight management for cancer prevention on the basis of the most comprehensive collection of available evidence. OBJECTIVE: We investigated whether concordance with WCRF/AICR recommendations is related to risk of death. DESIGN: The current study included 378,864 participants from 9 European countries enrolled in the European Prospective Investigation into Cancer and Nutrition study.

Vergnaud, Anne-Claire
Romaguera, Dora
Peeters, Petra H.
van Gils, Carla H.
Chan, Doris S. M.
Romieu, Isabelle
Freisling, Heinz
Ferrari, Pietro
Clavel-Chapelon, FranÁoise
Fagherazzi, Guy
Dartois, Laureen
Li, Kuanrong
Tikk, Kaja
Bergmann, Manuela M.
Boeing, Heiner
Tj¯nneland, Anne
Olsen, Anja
Overvad, Kim
Dahm, Christina C.
Redondo, Maria Luisa
Agudo, Antonio
S·nchez, MarÌa-JosÈ
Amiano, Pilar
Chirlaque, MarÌa-Dolores
Ardanaz, Eva
Khaw, Kay-Tee
Wareham, Nick J.
Crowe, Francesca
Trichopoulou, Antonia
Orfanos, Philippos
Trichopoulos, Dimitrios
Masala, Giovanna
Sieri, Sabina
Tumino, Rosario
Vineis, Paolo
Panico, Salvatore
Bueno-de-Mesquita, H. Bas
Ros, Martine M.
May, Anne
Wirf‰lt, Elisabet
Sonestedt, Emily
Johansson, Ingegerd
Hallmans, Gˆran
Lund, Eiliv
Weiderpass, Elisabete
Parr, Christine L.
Riboli, Elio
Norat, Teresa
Publication Title: 
Brain, Behavior, and Immunity

Major depressive disorder (MDD) has been associated with reduced leukocyte telomere length (LTL). It is not known, however, whether psychosocial and behavioral protective factors moderate this association. In the current study, we examine whether multisystem resiliency--defined by healthy emotion regulation, strong social connections, and health behaviors (sleep and exercise)--predicts LTL and mitigates previously demonstrated associations between depression diagnosis and LTL.

Puterman, Eli
Epel, Elissa S.
Lin, Jue
Blackburn, Elizabeth H.
Gross, James J.
Whooley, Mary A.
Cohen, Beth E.
Publication Title: 
PloS One

BACKGROUND: Telomeres shorten as cells divide. This shortening is compensated by the enzyme telomerase. We evaluated the effect of common variants in the telomerase RNA component (TERC) gene on telomere length (TL) in the population-based Health Aging and Body Composition (Health ABC) Study and in two replication samples (the TwinsUK Study and the Amish Family Osteoporosis Study, AFOS). METHODOLOGY: Five variants were identified in the TERC region by sequence analysis and only one SNP was common (rs2293607, G/A).

Njajou, Omer T.
Blackburn, Elizabeth H.
Pawlikowska, Ludmila
Mangino, Massimo
Damcott, Coleen M.
Kwok, Pui-Yan
Spector, Timothy D.
Newman, Anne B.
Harris, Tamara B.
Cummings, Steven R.
Cawthon, Richard M.
Shuldiner, Alan R.
Valdes, Ana M.
Hsueh, Wen-Chi


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