Colchicine

Publication Title: 
Mediators of Inflammation

Many diseases have been described to be associated with inflammatory processes. The currently available anti-inflammatory drug therapy is often not successful or causes intolerable side effects. Thus, new anti-inflammatory substances are still urgently needed. Plants were the first source of remedies in the history of mankind. Since their chemical characterization in the 19th century, herbal bioactive compounds have fueled drug development. Also, nowadays, new plant-derived agents continuously enrich our drug arsenal (e.g., vincristine, galantamine, and artemisinin).

Author(s): 
Fürst, Robert
Zündorf, Ilse
Publication Title: 
Journal of Alternative and Complementary Medicine (New York, N.Y.)

Trasina is a herbal formulation of some Indian medicinal plants classified in Ayurveda, the classic Indian system of medicine, as Medhyarasayanas or drugs reputed to improve memory and intellect. Earlier experimental and clinical investigations have indicated that the formulation has a memory-facilitating action. In this investigation, the effect of Trasina, after subchronic administration for 21 days, was assessed on two rodent models simulating some biochemical features known to be associated with Alzheimer's disease (AD).

Author(s): 
Bhattacharya, S. K.
Kumar, A.
Publication Title: 
American Journal of Physiology. Cell Physiology

Cytoskeleton-dependent changes in cell shape are well-established factors regulating a wide range of cellular functions including signal transduction, gene expression, and matrix adhesion. Although the importance of mechanical forces on cell shape and function is well established in cultured cells, very little is known about these effects in whole tissues or in vivo. In this study we used ex vivo and in vivo models to investigate the effect of tissue stretch on mouse subcutaneous tissue fibroblast morphology.

Author(s): 
Langevin, Helene M.
Bouffard, Nicole A.
Badger, Gary J.
Iatridis, James C.
Howe, Alan K.
Publication Title: 
Journal of Cellular Physiology

The visco-elastic behavior of connective tissue is generally attributed to the material properties of the extracellular matrix rather than cellular activity. We have previously shown that fibroblasts within areolar connective tissue exhibit dynamic cytoskeletal remodeling within minutes in response to tissue stretch ex vivo and in vivo. Here, we tested the hypothesis that fibroblasts, through this cytoskeletal remodeling, actively contribute to the visco-elastic behavior of the whole tissue.

Author(s): 
Langevin, Helene M.
Bouffard, Nicole A.
Fox, James R.
Palmer, Bradley M.
Wu, Junru
Iatridis, James C.
Barnes, William D.
Badger, Gary J.
Howe, Alan K.
Publication Title: 
American Journal of Physiology. Cell Physiology

Cytoskeleton-dependent changes in cell shape are well-established factors regulating a wide range of cellular functions including signal transduction, gene expression, and matrix adhesion. Although the importance of mechanical forces on cell shape and function is well established in cultured cells, very little is known about these effects in whole tissues or in vivo. In this study we used ex vivo and in vivo models to investigate the effect of tissue stretch on mouse subcutaneous tissue fibroblast morphology.

Author(s): 
Langevin, Helene M.
Bouffard, Nicole A.
Badger, Gary J.
Iatridis, James C.
Howe, Alan K.
Publication Title: 
Mutagenesis

The chromosomal composition of micronuclei (MN) induced by the model mutagens mitomycin (MMC) and colchicine (COL) as well as by acrylamide (AA) and the traditional Chinese medicine Tripterygium hypoglaucum (level) hutch (THH) in NIH 3T3 cells was analyzed by multicolor fluorescence in situ hybridization (FISH) using DNA probes for the centromere repeated minor satellite DNA and the telomeric hexamer repeat (TTAGGG). The majority of MN (78.6%) from treatment with MMC (0.1 microg/ml) did not show centromeric signals, reflecting the clastogenic action of MMC.

Author(s): 
Jie, Y. M.
Jia, C.
Publication Title: 
Acta Pharmacologica Sinica

Endotoxin (ET) was found to have wide bioactivities and ET antagonists have become the pop research topic in life science. The chemical components of traditional Chinese medicine (TCM) were the substance basis of its pharmacology. This review demonstrated the study state of about 18 chemical components from TCM, eg, organic acids of Radix Isatidis, anisodamine, matrine, tetramethypyrazine, colchicine, and glycine, etc, which showed anti-endotoxin effects through different routes. But now the most of them were limited to the laboratory.

Author(s): 
Liu, Y. H.
Liu, Y. F.
Guo, X. X.
Publication Title: 
Clinical Cancer Research: An Official Journal of the American Association for Cancer Research

PURPOSE: Pseudolaric acid B (PAB) is the major bioactive constituent in the root bark of Pseudolarix kaempferi that has been used as an antifungal remedy in traditional Chinese medicine. Previous studies showed that PAB exhibited substantial cytotoxicity. The aims of this study were to elucidate the molecular target of PAB, to examine its mechanism of action, and to evaluate the efficacy of this compound in vivo. EXPERIMENTAL DESIGN: The effect of PAB on cell growth inhibition toward a panel of cancer cell lines was assayed.

Author(s): 
Wong, Vincent K. W.
Chiu, Pauline
Chung, Stephen S. M.
Chow, Larry M. C.
Zhao, Yun-Zhe
Yang, Burton B.
Ko, Ben C. B.
Publication Title: 
American Journal of Physiology. Cell Physiology

Cytoskeleton-dependent changes in cell shape are well-established factors regulating a wide range of cellular functions including signal transduction, gene expression, and matrix adhesion. Although the importance of mechanical forces on cell shape and function is well established in cultured cells, very little is known about these effects in whole tissues or in vivo. In this study we used ex vivo and in vivo models to investigate the effect of tissue stretch on mouse subcutaneous tissue fibroblast morphology.

Author(s): 
Langevin, Helene M.
Bouffard, Nicole A.
Badger, Gary J.
Iatridis, James C.
Howe, Alan K.
Publication Title: 
PloS One

BACKGROUND: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) has been treated with several different interventions with limited success. This meta-analysis aims to review all trials reporting on therapeutic intervention for CP/CPPS using the National Institutes of Health-Chronic Prostatitis Symptom Index (NIH-CPSI).

Author(s): 
Cohen, Jeffrey M.
Fagin, Adam P.
Hariton, Eduardo
Niska, Joshua R.
Pierce, Michael W.
Kuriyama, Akira
Whelan, Julia S.
Jackson, Jeffrey L.
Dimitrakoff, Jordan D.
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