Colforsin

Publication Title: 
The Journal of Pharmacology and Experimental Therapeutics

An extract of the plant Coleus forskohlii has been used for centuries in Ayurvedic medicine to treat various diseases such as hypothyroidism, heart disease, and respiratory disorders. Additionally, complex herbal mixtures containing this extract are gaining popularity in United States for their putative "fat-burning" properties. The active ingredient in C. forskohlii extract is the diterpene compound forskolin.

Author(s): 
Ding, Xunshan
Staudinger, Jeff L.
Publication Title: 
The Journal of Pharmacology and Experimental Therapeutics

An extract of the plant Coleus forskohlii has been used for centuries in Ayurvedic medicine to treat various diseases such as hypothyroidism, heart disease, and respiratory disorders. Additionally, complex herbal mixtures containing this extract are gaining popularity in United States for their putative "fat-burning" properties. The active ingredient in C. forskohlii extract is the diterpene compound forskolin.

Author(s): 
Ding, Xunshan
Staudinger, Jeff L.
Publication Title: 
Planta Medica

Plectranthus barbatus Andr. is one of the most important species of the genus Plectranthus L' Herit. (Lamiaceae), with a wide variety of traditional medicinal uses in Hindu and Ayurvedic traditional medicine as well as in the folk medicine of Brazil, tropical Africa and China. The plant has therefore been an attractive target for intensive chemical and pharmacological studies up to now. This review presents data about the phytochemistry, ethnobotanical uses and pharmacology of Plectranthus barbatus as well as the pharmacology of its constituents.

Author(s): 
Alasbahi, Rawiya H.
Melzig, Matthias F.
Publication Title: 
Planta Medica

Plectranthus barbatus andr. is one of the most important species of the genus Plectranthus L' Herit. (Lamiaceae), with a wide variety of traditional medicinal uses in Hindu and Ayurvedic traditional medicine as well as in the folk medicine of Brazil, tropical Africa and China. The plant has therefore been an attractive target for intensive chemical and pharmacological studies up to now. This review presents data about the phytochemistry, ethnobotanical uses and pharmacology of Plectranthus barbatus as well as the pharmacology of its constituents.

Author(s): 
Alasbahi, Rawiya H.
Melzig, Matthias F.
Publication Title: 
American Journal of Physiology. Lung Cellular and Molecular Physiology

Activation of an innate immune response in airway epithelia by the human pathogen Pseudomonas aeruginosa requires bacterial expression of flagellin. Addition of flagellin (10(-7) M) to airway epithelial cell monolayers (Calu-3, airway serous cell-like) increased Cl(-) secretion (I(Cl)) beginning after 3-10 min, reaching a plateau after 20-45 min at DeltaI(Cl) = 15-50 microA/cm(2). Similar, although 10-fold smaller, responses were observed in well-differentiated bronchial epithelial cultures.

Author(s): 
Illek, Beate
Fu, Zhu
Schwarzer, Christian
Banzon, Tina
Jalickee, Stephen
Miller, Sheldon S.
Machen, Terry E.
Publication Title: 
Cellular Physiology and Biochemistry: International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology

The flavone apigenin has been previously selected as a potent pharmacological activator of the CFTR Cl(-) channel, however, its utility for the activation of CFTR in vivo is expected to be limited because flavonoids are readily metabolized. We therefore investigated the poorly metabolizable methylether of apigenin, 5,7,4'-trimethoxyflavone (TMF) as a CFTR activator using transepithelial short-circuit current measurements, whole cell and single cell patch clamp techniques, and nasal potential difference (PD) measurements.

Author(s): 
Fischer, Horst
Illek, Beate
Publication Title: 
American Journal of Rhinology & Allergy

BACKGROUND: Chronic rhinosinusitis (CRS) occurs at high frequency in patients with cystic fibrosis, suggesting that the cystic fibrosis transmembrane conductance regulator (CFTR) chloride (Cl) ion channel might be involved in the development of chronic sinusitis in the general population. CFTR Cl ion transport controls the hydration of mucosal surfaces and promotes effective mucociliary clearance. Altered ion transport and, hence, disrupted mucociliary function, could play a role in the pathogenesis of sinus disease.

Author(s): 
Cho, Do-Yeon
Hwang, Peter H.
Illek, Beate
Publication Title: 
The Laryngoscope

OBJECTIVES/HYPOTHESIS: Primary ciliary dyskinesia (PCD) is an inherited disorder that produces lifelong difficulties with chronic airway inflammation. Little is known about the role of chronic airway inflammation on chloride ion transport properties in PCD. This study assessed the cyclic adenosine monophosphate (cAMP)-regulated chloride (Cl) ion transport properties of freshly excised nasal mucosa from PCD compared with normal and chronic rhinosinusitis (CRS).

Author(s): 
Cho, Do-Yeon
Hwang, Peter H.
Illek, Beate
Publication Title: 
FASEB journal: official publication of the Federation of American Societies for Experimental Biology

Growth hormone (GH) is a major anabolic hormone and the primary regulator of organism growth. Its transcription is triggered by GH-releasing hormone (GHRH) through the transcription factor cAMP response element-binding protein (CREB) and by caloric intake. In contrast, the deacetylase Sirt1 is activated by caloric restriction. Therefore, the present study investigates how Sirt1 affects CREB function and GH synthesis.

Author(s): 
Monteserin-Garcia, Jose
Al-Massadi, Omar
Seoane, Luisa M.
Alvarez, Clara V.
Shan, Bing
Stalla, Johanna
Paez-Pereda, Marcelo
Casanueva, Felipe F.
Stalla, Günter K.
Theodoropoulou, Marily
Publication Title: 
The Journal of Investigative Dermatology

The microphthalmia-associated transcription factor is implicated in melanocyte development and in the regulation of melanogenesis. Microphthalmia-associated transcription factor is thought to bind to the M-box promoter elements of tyrosinase, tyrosinase-related protein-1 and dopachrome tautomerase/tyrosinase-related protein-2 and transactivate these genes, resulting in increased pigmentation.

Author(s): 
Lin, C. B.
Babiarz, L.
Liebel, F.
Roydon Price, E.
Kizoulis, M.
Gendimenico, G. J.
Fisher, D. E.
Seiberg, M.
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