Depressive Disorder, Major

Publication Title: 
International Journal of Yoga Therapy

SYR 2013 Accepted Poster abstracts: 1. Benefits of Yoga as a Wellness Practice in a Veterans Affairs (VA) Health Care Setting: If You Build It, Will They Come? 2. Yoga-based Psychotherapy Group With Urban Youth Exposed to Trauma. 3. Embodied Health: The Effects of a Mind?Body Course for Medical Students. 4. Interoceptive Awareness and Vegetable Intake After a Yoga and Stress Management Intervention. 5. Yoga Reduces Performance Anxiety in Adolescent Musicians. 6. Designing and Implementing a Therapeutic Yoga Program for Older Women With Knee Osteoarthritis. 7.

Publication Title: 
Bulletin of the Menninger Clinic

A new retrospective interview assessment of childhood psychological abuse, an extension to the Childhood Experience of Care and Abuse (CECA) instrument, is described in a companion article (Moran, Bifulco, Ball, Jacobs, & Benaim, 2002). The purpose of the present article is to examine the relationship of childhood psychological abuse to other adverse childhood experiences and to major depression and suicidal behavior in adult life. Childhood experience and lifetime disorder were assessed retrospectively in a high-risk, community series of London women (n = 204).

Author(s): 
Bifulco, Antonia
Moran, Patricia M.
Baines, Rebecca
Bunn, Amanda
Stanford, Katherine
Publication Title: 
Brain, Behavior, and Immunity

Major depressive disorder (MDD) has been associated with reduced leukocyte telomere length (LTL). It is not known, however, whether psychosocial and behavioral protective factors moderate this association. In the current study, we examine whether multisystem resiliency--defined by healthy emotion regulation, strong social connections, and health behaviors (sleep and exercise)--predicts LTL and mitigates previously demonstrated associations between depression diagnosis and LTL.

Author(s): 
Puterman, Eli
Epel, Elissa S.
Lin, Jue
Blackburn, Elizabeth H.
Gross, James J.
Whooley, Mary A.
Cohen, Beth E.
Publication Title: 
Molecular Psychiatry

Telomeres are DNA-protein complexes that cap linear DNA strands, protecting DNA from damage. When telomeres critically shorten, cells become susceptible to senescence and apoptosis. Telomerase, a cellular ribonucleoprotein enzyme, rebuilds the length of telomeres and promotes cellular viability. Leukocyte telomeres are reportedly shortened in major depression, but telomerase activity in depression has not been previously reported.

Author(s): 
Wolkowitz, O. M.
Mellon, S. H.
Epel, E. S.
Lin, J.
Reus, V. I.
Rosser, R.
Burke, H.
Compagnone, M.
Nelson, J. C.
Dhabhar, F. S.
Blackburn, E. H.
Publication Title: 
PloS One

BACKGROUND: Depression is associated with an unusually high rate of aging-related illnesses and early mortality. One aspect of "accelerated aging" in depression may be shortened leukocyte telomeres. When telomeres critically shorten, as often occurs with repeated mitoses or in response to oxidation and inflammation, cells may die. Indeed, leukocyte telomere shortening predicts early mortality and medical illnesses in non-depressed populations.

Author(s): 
Wolkowitz, Owen M.
Mellon, Synthia H.
Epel, Elissa S.
Lin, Jue
Dhabhar, Firdaus S.
Su, Yali
Reus, Victor I.
Rosser, Rebecca
Burke, Heather M.
Kupferman, Eve
Compagnone, Mariana
Nelson, J. Craig
Blackburn, Elizabeth H.
Publication Title: 
Psychosomatic Medicine

OBJECTIVE: Shortened telomere length has been associated with mortality in patients with coronary heart disease (CHD) and is considered as an emerging marker of biologic age. Whether depression is associated with telomere length or trajectory has not been evaluated in patients with CHD. METHODS: In a prospective cohort study, we measured leukocyte telomere length in 952 participants with stable CHD at baseline and in 608 of these participants after 5 years of follow-up.

Author(s): 
Hoen, Petra W.
de Jonge, Peter
Na, Bee Ya
Farzaneh-Far, Ramin
Epel, Elissa
Lin, Jue
Blackburn, Elizabeth
Whooley, Mary A.
Publication Title: 
Psychosomatic Medicine

OBJECTIVE: Shortened telomere length has been associated with mortality in patients with coronary heart disease (CHD) and is considered as an emerging marker of biologic age. Whether depression is associated with telomere length or trajectory has not been evaluated in patients with CHD. METHODS: In a prospective cohort study, we measured leukocyte telomere length in 952 participants with stable CHD at baseline and in 608 of these participants after 5 years of follow-up.

Author(s): 
Hoen, Petra W.
de Jonge, Peter
Na, Bee Ya
Farzaneh-Far, Ramin
Epel, Elissa
Lin, Jue
Blackburn, Elizabeth
Whooley, Mary A.
Publication Title: 
Brain, Behavior, and Immunity

Major depressive disorder (MDD) has been associated with reduced leukocyte telomere length (LTL). It is not known, however, whether psychosocial and behavioral protective factors moderate this association. In the current study, we examine whether multisystem resiliency--defined by healthy emotion regulation, strong social connections, and health behaviors (sleep and exercise)--predicts LTL and mitigates previously demonstrated associations between depression diagnosis and LTL.

Author(s): 
Puterman, Eli
Epel, Elissa S.
Lin, Jue
Blackburn, Elizabeth H.
Gross, James J.
Whooley, Mary A.
Cohen, Beth E.
Publication Title: 
Journal of Psychiatric Research

Elevated circulating pro-inflammatory cytokines are associated with symptoms of depression, and disorders involving chronic inflammation are often co-morbid with major depression. Since healthy immune regulation is accomplished through counter-balancing effects of pro- and anti-inflammatory cytokines, we hypothesized that depressed subjects (compared to controls) would express lower concentrations of the anti-inflammatory/immunoregulatory cytokine interleukin (IL)-10, and a higher IL-6/IL-10 ratio.

Author(s): 
Dhabhar, Firdaus S.
Burke, Heather M.
Epel, Elissa S.
Mellon, Synthia H.
Rosser, Rebecca
Reus, Victor I.
Wolkowitz, Owen M.
Publication Title: 
Brain, Behavior, and Immunity

Chronic inflammation and oxidative stress have been implicated in the pathophysiology of Major Depressive Disorder (MDD), as well as in a number of chronic medical conditions. The aim of this study was to examine the relationship between peripheral inflammatory and oxidative stress markers in un-medicated subjects with MDD compared to non-depressed healthy controls and compared to subjects with MDD after antidepressant treatment. We examined the relationships between IL-6, IL-10, and the IL-6/IL-10 inflammatory ratio vs.

Author(s): 
Rawdin, B. J.
Mellon, S. H.
Dhabhar, F. S.
Epel, E. S.
Puterman, E.
Su, Y.
Burke, H. M.
Reus, V. I.
Rosser, R.
Hamilton, S. P.
Nelson, J. C.
Wolkowitz, O. M.

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