Diabetic Foot

Publication Title: 
Diabetic Medicine: A Journal of the British Diabetic Association

BACKGROUND: Foot ulcers in diabetes are associated with increased mortality, illness and reduced quality of life. Ulcer infection impairs healing and antimicrobial interventions may cure infection, aid healing and reduce amputation rates. OBJECTIVES: To systematically review the evidence for antimicrobial interventions for foot ulcers in diabetes. METHODS: We searched 16 databases, 11 Internet sites, three books, conference proceedings, a journal and bibliographies in November 2002. We included randomized controlled trials (RCTs) or controlled clinical trials (CCTs).

Author(s): 
Nelson, E. A.
O'Meara, S.
Golder, S.
Dalton, J.
Craig, D.
Iglesias, C.
DASIDU Steering Group
Publication Title: 
Health Technology Assessment (Winchester, England)

OBJECTIVES: To review systematically the evidence on the performance of diagnostic tests used to identify infection in diabetic foot ulcers (DFUs) and of interventions to treat infected DFUs. To use estimates derived from the systematic reviews to create a decision analytic model in order to identify the most effective method of diagnosing and treating infection and to identify areas of research that would lead to large reductions in clinical uncertainty. DATA SOURCES: Electronic databases covering period from inception of the database to November 2002.

Author(s): 
Nelson, E. A.
O'Meara, S.
Craig, D.
Iglesias, C.
Golder, S.
Dalton, J.
Claxton, K.
Bell-Syer, S. E. M.
Jude, E.
Dowson, C.
Gadsby, R.
O'Hare, P.
Powell, J.
Publication Title: 
Health Technology Assessment (Winchester, England)

OBJECTIVES: To review systematically the evidence on the performance of diagnostic tests used to identify infection in diabetic foot ulcers (DFUs) and of interventions to treat infected DFUs. To use estimates derived from the systematic reviews to create a decision analytic model in order to identify the most effective method of diagnosing and treating infection and to identify areas of research that would lead to large reductions in clinical uncertainty. DATA SOURCES: Electronic databases covering period from inception of the database to November 2002.

Author(s): 
Nelson, E. A.
O'Meara, S.
Craig, D.
Iglesias, C.
Golder, S.
Dalton, J.
Claxton, K.
Bell-Syer, S. E. M.
Jude, E.
Dowson, C.
Gadsby, R.
O'Hare, P.
Powell, J.
Publication Title: 
Health Technology Assessment (Winchester, England)

OBJECTIVES: To review systematically the evidence on the performance of diagnostic tests used to identify infection in diabetic foot ulcers (DFUs) and of interventions to treat infected DFUs. To use estimates derived from the systematic reviews to create a decision analytic model in order to identify the most effective method of diagnosing and treating infection and to identify areas of research that would lead to large reductions in clinical uncertainty. DATA SOURCES: Electronic databases covering period from inception of the database to November 2002.

Author(s): 
Nelson, E. A.
O'Meara, S.
Craig, D.
Iglesias, C.
Golder, S.
Dalton, J.
Claxton, K.
Bell-Syer, S. E. M.
Jude, E.
Dowson, C.
Gadsby, R.
O'Hare, P.
Powell, J.
Publication Title: 
Diabetic Medicine: A Journal of the British Diabetic Association

BACKGROUND: Foot ulcers in diabetes are associated with increased mortality, illness and reduced quality of life. Ulcer infection impairs healing and antimicrobial interventions may cure infection, aid healing and reduce amputation rates. OBJECTIVES: To systematically review the evidence for antimicrobial interventions for foot ulcers in diabetes. METHODS: We searched 16 databases, 11 Internet sites, three books, conference proceedings, a journal and bibliographies in November 2002. We included randomized controlled trials (RCTs) or controlled clinical trials (CCTs).

Author(s): 
Nelson, E. A.
O'Meara, S.
Golder, S.
Dalton, J.
Craig, D.
Iglesias, C.
DASIDU Steering Group
Publication Title: 
Journal of Diabetes and Its Complications

BACKGROUND: In diabetes, foot ulceration may result from increased skin fragility. Retinoids can reverse some diabetes-induced deficits of skin structure and function, but their clinical utility is limited by skin irritation. The effects of diabetes and MDI 301, a nonirritating synthetic retinoid, and retinoic acid have been evaluated on matrix metalloproteinases (MMPs), procollagen expression, and skin structure in skin biopsies from nondiabetic volunteers and diabetic subjects at risk of foot ulceration using organ culture techniques.

Author(s): 
Zeng, Wei
Tahrani, Abd
Shakher, Jayadave
Varani, James
Hughes, Sharon
Dubb, Kiran
Stevens, Martin J.
Publication Title: 
Journal of Manipulative and Physiological Therapeutics

OBJECTIVE: To discuss a case involving a 55-year-old diabetic woman with neuropathic osteoarthropathy initiated by a fall. CLINICAL FEATURES: The patient fell into a hole, injuring her left foot. Because of the anesthesia associated with her diabetic peripheral neuropathy, she did not notice the ensuing plantar puncture wound. The patient assumed that her swelling was a result of a sprain. Mild dislocation and osseous fragmentation was noted within the midfoot on radiographs. The neuropathic osteoarthropathy progressed until the patient was later casted.

Author(s): 
Osterhouse, Melanie D.
Kettner, Norman W.
Publication Title: 
Journal of Manipulative and Physiological Therapeutics

OBJECTIVE: To discuss a case involving a 55-year-old diabetic woman with neuropathic osteoarthropathy initiated by a fall. CLINICAL FEATURES: The patient fell into a hole, injuring her left foot. Because of the anesthesia associated with her diabetic peripheral neuropathy, she did not notice the ensuing plantar puncture wound. The patient assumed that her swelling was a result of a sprain. Mild dislocation and osseous fragmentation was noted within the midfoot on radiographs. The neuropathic osteoarthropathy progressed until the patient was later casted.

Author(s): 
Osterhouse, Melanie D.
Kettner, Norman W.
Publication Title: 
Zhong Xi Yi Jie He Xue Bao = Journal of Chinese Integrative Medicine

BACKGROUND: Many studies have demonstrated association between advanced glycation end products (AGEs) and diabetic angiopathy. There are certain advantages of traditional Chinese medicine (TCM) therapy in treatment of these diseases. OBJECTIVE: To evaluate the therapeutic effects and safety of modified Danggui Sini Decoction, a compound traditional Chinese herbal medicine for nourishing blood to warm meridians, on plasma level of AGEs in patients with Wagner grade 0 diabetic foot ulcers of blood stasis or/and kidney yang deficiency syndrome.

Author(s): 
You, Wei-hua
Wang, Ping
Li, Mao-qing
Zhang, Yu
Peng, Yu-lan
Zhang, Feng-ling
Publication Title: 
Ostomy/Wound Management

Pulsed radio frequency energy (PRFE) has been shown to stimulate cultured epidermal cells in vitro, inciting a cascade of cytokines, cyclins, growth factors, and other gene products associated with wound healing. A retrospective, descriptive study was conducted to evaluate the effect of PRFE on healing lower extremity wounds.

Author(s): 
Frykberg, Robert G.
Driver, Vickie R.
Lavery, Lawrence A.
Armstrong, David G.
Isenberg, Richard A.

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